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A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection

Aim: Concerns have been raised about possible neuropsychiatric sequelae of COVID-19. The objective of this study was to examine the plausibility of long-term mental health consequences of COVID-19 by assessing a sample of children after the resolution of the acute SARS-CoV-2 infection. Method: As pa...

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Autores principales: Scarselli, Veronica, Calderoni, Dario, Terrinoni, Arianna, Davico, Chiara, Pruccoli, Giulia, Denina, Marco, Carducci, Chiara, Smarrazzo, Andrea, Martucci, Melania, Presicce, Mariaelena, Marcotulli, Daniele, Arletti, Luca, Ferrara, Mauro, Garazzino, Silvia, Mariani, Rosanna, Campana, Andrea, Vitiello, Benedetto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298991/
https://www.ncbi.nlm.nih.gov/pubmed/37373611
http://dx.doi.org/10.3390/jcm12123917
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author Scarselli, Veronica
Calderoni, Dario
Terrinoni, Arianna
Davico, Chiara
Pruccoli, Giulia
Denina, Marco
Carducci, Chiara
Smarrazzo, Andrea
Martucci, Melania
Presicce, Mariaelena
Marcotulli, Daniele
Arletti, Luca
Ferrara, Mauro
Garazzino, Silvia
Mariani, Rosanna
Campana, Andrea
Vitiello, Benedetto
author_facet Scarselli, Veronica
Calderoni, Dario
Terrinoni, Arianna
Davico, Chiara
Pruccoli, Giulia
Denina, Marco
Carducci, Chiara
Smarrazzo, Andrea
Martucci, Melania
Presicce, Mariaelena
Marcotulli, Daniele
Arletti, Luca
Ferrara, Mauro
Garazzino, Silvia
Mariani, Rosanna
Campana, Andrea
Vitiello, Benedetto
author_sort Scarselli, Veronica
collection PubMed
description Aim: Concerns have been raised about possible neuropsychiatric sequelae of COVID-19. The objective of this study was to examine the plausibility of long-term mental health consequences of COVID-19 by assessing a sample of children after the resolution of the acute SARS-CoV-2 infection. Method: As part of a systematic follow-up assessment of pediatric patients with COVID-19 conducted at two university children’s hospitals, 50 children (56% males) aged 8 to 17 years (median 11.5), 26% with previous multisystem inflammatory syndrome in children (MIS-C), without a prior history of neuropsychiatric disorders, received a battery of clinical neuropsychiatric and neuropsychological rating scales that included the Pediatric Migraine Disability Assessment (PedMIDAS), Sleep Disturbance Scale for Children (SDSC), Multidimensional Anxiety Scale for Children (MASC-2), Child Depression Inventory (CDI-2), Child Behavior Checklist (CBCL), and the NEPSY II (Neuropsychological Assessment, Second Edition). The assessments were conducted between 1 and 18 months (median 8 months) after the acute infection. Results: The CBCL internalizing symptoms score was in the clinical range for 40% of the participants (vs. a population expected rate of about 10%, p < 0.001). A sleep disturbance was detected in 28%, clinically significant anxiety in 48%, and depressive symptoms in 16%. The NEPSY II scores showed impairment in attention and other executive functions in 52%, and memory deficits in 40% of the children. Conclusions: These data from direct assessment of a sample of children who had SARS-CoV-2 infection show higher than expected rates of neuropsychiatric symptoms, thus supporting the possibility that COVID-19 may have mental health sequelae long after the resolution of the acute infection.
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spelling pubmed-102989912023-06-28 A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection Scarselli, Veronica Calderoni, Dario Terrinoni, Arianna Davico, Chiara Pruccoli, Giulia Denina, Marco Carducci, Chiara Smarrazzo, Andrea Martucci, Melania Presicce, Mariaelena Marcotulli, Daniele Arletti, Luca Ferrara, Mauro Garazzino, Silvia Mariani, Rosanna Campana, Andrea Vitiello, Benedetto J Clin Med Article Aim: Concerns have been raised about possible neuropsychiatric sequelae of COVID-19. The objective of this study was to examine the plausibility of long-term mental health consequences of COVID-19 by assessing a sample of children after the resolution of the acute SARS-CoV-2 infection. Method: As part of a systematic follow-up assessment of pediatric patients with COVID-19 conducted at two university children’s hospitals, 50 children (56% males) aged 8 to 17 years (median 11.5), 26% with previous multisystem inflammatory syndrome in children (MIS-C), without a prior history of neuropsychiatric disorders, received a battery of clinical neuropsychiatric and neuropsychological rating scales that included the Pediatric Migraine Disability Assessment (PedMIDAS), Sleep Disturbance Scale for Children (SDSC), Multidimensional Anxiety Scale for Children (MASC-2), Child Depression Inventory (CDI-2), Child Behavior Checklist (CBCL), and the NEPSY II (Neuropsychological Assessment, Second Edition). The assessments were conducted between 1 and 18 months (median 8 months) after the acute infection. Results: The CBCL internalizing symptoms score was in the clinical range for 40% of the participants (vs. a population expected rate of about 10%, p < 0.001). A sleep disturbance was detected in 28%, clinically significant anxiety in 48%, and depressive symptoms in 16%. The NEPSY II scores showed impairment in attention and other executive functions in 52%, and memory deficits in 40% of the children. Conclusions: These data from direct assessment of a sample of children who had SARS-CoV-2 infection show higher than expected rates of neuropsychiatric symptoms, thus supporting the possibility that COVID-19 may have mental health sequelae long after the resolution of the acute infection. MDPI 2023-06-08 /pmc/articles/PMC10298991/ /pubmed/37373611 http://dx.doi.org/10.3390/jcm12123917 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scarselli, Veronica
Calderoni, Dario
Terrinoni, Arianna
Davico, Chiara
Pruccoli, Giulia
Denina, Marco
Carducci, Chiara
Smarrazzo, Andrea
Martucci, Melania
Presicce, Mariaelena
Marcotulli, Daniele
Arletti, Luca
Ferrara, Mauro
Garazzino, Silvia
Mariani, Rosanna
Campana, Andrea
Vitiello, Benedetto
A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
title A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
title_full A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
title_fullStr A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
title_full_unstemmed A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
title_short A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
title_sort neuropsychiatric assessment of children with previous sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298991/
https://www.ncbi.nlm.nih.gov/pubmed/37373611
http://dx.doi.org/10.3390/jcm12123917
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