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Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings

The polylactic acid-glycolic acid copolymer (PLGA) has been proven to be applicable in medicine, but there is limited research on its application and safety in the agricultural field. In this paper, thifluzamide PLGA microspheres were prepared via phacoemulsification and solvent volatilization, usin...

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Detalles Bibliográficos
Autores principales: Li, Yuanyuan, Wang, Chaojie, Deng, Xile, Cai, Runze, Cao, Lidong, Cao, Chong, Zheng, Li, Zhao, Pengyue, Huang, Qiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299088/
https://www.ncbi.nlm.nih.gov/pubmed/37373269
http://dx.doi.org/10.3390/ijms241210121
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author Li, Yuanyuan
Wang, Chaojie
Deng, Xile
Cai, Runze
Cao, Lidong
Cao, Chong
Zheng, Li
Zhao, Pengyue
Huang, Qiliang
author_facet Li, Yuanyuan
Wang, Chaojie
Deng, Xile
Cai, Runze
Cao, Lidong
Cao, Chong
Zheng, Li
Zhao, Pengyue
Huang, Qiliang
author_sort Li, Yuanyuan
collection PubMed
description The polylactic acid-glycolic acid copolymer (PLGA) has been proven to be applicable in medicine, but there is limited research on its application and safety in the agricultural field. In this paper, thifluzamide PLGA microspheres were prepared via phacoemulsification and solvent volatilization, using the PLGA copolymer as the carrier and thifluzamide as the active component. It was found that the microspheres had good slow-release performance and fungicidal activity against Rhizoctonia solani. A comparative study was conducted to show the effect of thifluzamide PLGA microspheres on cucumber seedlings. Physiological and biochemical indexes of cucumber seedlings, including dry weight, root length, chlorophyll, protein, flavonoids, and total phenol content, indicated that the negative effect of thifluzamide on plant growth could be mitigated when it was wrapped in PLGA microspheres. This work explores the feasibility of PLGA as carriers in fungicide applications.
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spelling pubmed-102990882023-06-28 Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings Li, Yuanyuan Wang, Chaojie Deng, Xile Cai, Runze Cao, Lidong Cao, Chong Zheng, Li Zhao, Pengyue Huang, Qiliang Int J Mol Sci Article The polylactic acid-glycolic acid copolymer (PLGA) has been proven to be applicable in medicine, but there is limited research on its application and safety in the agricultural field. In this paper, thifluzamide PLGA microspheres were prepared via phacoemulsification and solvent volatilization, using the PLGA copolymer as the carrier and thifluzamide as the active component. It was found that the microspheres had good slow-release performance and fungicidal activity against Rhizoctonia solani. A comparative study was conducted to show the effect of thifluzamide PLGA microspheres on cucumber seedlings. Physiological and biochemical indexes of cucumber seedlings, including dry weight, root length, chlorophyll, protein, flavonoids, and total phenol content, indicated that the negative effect of thifluzamide on plant growth could be mitigated when it was wrapped in PLGA microspheres. This work explores the feasibility of PLGA as carriers in fungicide applications. MDPI 2023-06-14 /pmc/articles/PMC10299088/ /pubmed/37373269 http://dx.doi.org/10.3390/ijms241210121 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yuanyuan
Wang, Chaojie
Deng, Xile
Cai, Runze
Cao, Lidong
Cao, Chong
Zheng, Li
Zhao, Pengyue
Huang, Qiliang
Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
title Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
title_full Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
title_fullStr Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
title_full_unstemmed Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
title_short Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
title_sort preparation of thifluzamide polylactic acid glycolic acid copolymer microspheres and its effect on the growth of cucumber seedlings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299088/
https://www.ncbi.nlm.nih.gov/pubmed/37373269
http://dx.doi.org/10.3390/ijms241210121
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