Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique car...

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Autores principales: O’Brien, Barry, Reilly, John, Coffey, Ken, González-Suárez, Ana, Quinlan, Leo, van Zyl, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299113/
https://www.ncbi.nlm.nih.gov/pubmed/37367403
http://dx.doi.org/10.3390/jcdd10060238
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author O’Brien, Barry
Reilly, John
Coffey, Ken
González-Suárez, Ana
Quinlan, Leo
van Zyl, Martin
author_facet O’Brien, Barry
Reilly, John
Coffey, Ken
González-Suárez, Ana
Quinlan, Leo
van Zyl, Martin
author_sort O’Brien, Barry
collection PubMed
description Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique cardioneuroablation technique for the modulation of the cardiac ANS as a potential treatment for AF. The treatment uses pulsed electric field energy to selectively electroporate ANS structures on the epicardial surface of the heart. Insights from in vitro studies and electric field models are presented as well as data from both pre-clinical and early clinical studies.
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spelling pubmed-102991132023-06-28 Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation O’Brien, Barry Reilly, John Coffey, Ken González-Suárez, Ana Quinlan, Leo van Zyl, Martin J Cardiovasc Dev Dis Review Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique cardioneuroablation technique for the modulation of the cardiac ANS as a potential treatment for AF. The treatment uses pulsed electric field energy to selectively electroporate ANS structures on the epicardial surface of the heart. Insights from in vitro studies and electric field models are presented as well as data from both pre-clinical and early clinical studies. MDPI 2023-05-29 /pmc/articles/PMC10299113/ /pubmed/37367403 http://dx.doi.org/10.3390/jcdd10060238 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
O’Brien, Barry
Reilly, John
Coffey, Ken
González-Suárez, Ana
Quinlan, Leo
van Zyl, Martin
Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
title Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
title_full Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
title_fullStr Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
title_full_unstemmed Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
title_short Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
title_sort cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299113/
https://www.ncbi.nlm.nih.gov/pubmed/37367403
http://dx.doi.org/10.3390/jcdd10060238
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