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Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature

Modular megaprostheses (MPs) are commonly used after bone-tumor resection, but they can offer a limb salvage solution in massive bone defects. The aim of this systematic review of the Literature is to provide a comprehensive data collection concerning the use of MPs in non-oncologic cases, and to pr...

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Autores principales: Sambri, Andrea, Parisi, Stefania Claudia, Zunarelli, Renato, Di Prinzio, Lorenzo, Morante, Lorenzo, Lonardo, Gianluca, Bortoli, Marta, Montanari, Andrea, De Cristofaro, Roberto, Fiore, Michele, De Paolis, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299121/
https://www.ncbi.nlm.nih.gov/pubmed/37373844
http://dx.doi.org/10.3390/jcm12124151
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author Sambri, Andrea
Parisi, Stefania Claudia
Zunarelli, Renato
Di Prinzio, Lorenzo
Morante, Lorenzo
Lonardo, Gianluca
Bortoli, Marta
Montanari, Andrea
De Cristofaro, Roberto
Fiore, Michele
De Paolis, Massimiliano
author_facet Sambri, Andrea
Parisi, Stefania Claudia
Zunarelli, Renato
Di Prinzio, Lorenzo
Morante, Lorenzo
Lonardo, Gianluca
Bortoli, Marta
Montanari, Andrea
De Cristofaro, Roberto
Fiore, Michele
De Paolis, Massimiliano
author_sort Sambri, Andrea
collection PubMed
description Modular megaprostheses (MPs) are commonly used after bone-tumor resection, but they can offer a limb salvage solution in massive bone defects. The aim of this systematic review of the Literature is to provide a comprehensive data collection concerning the use of MPs in non-oncologic cases, and to provide an overview of this topic, especially from an epidemiologic point of view. Three different databases (PubMed, Scopus, and Web of Science) were searched for relevant articles, and further references were obtained by cross-referencing. Sixty-nine studies met the inclusion criteria, reporting on cases of MP in non-oncologic cases. A total of 2598 MPs were retrieved. Among these, 1353 (52.1%) were distal femur MPs, 941 (36.2%) were proximal femur MPs, 29 (1.4%) were proximal tibia MPs and 259 (10.0%) were total femur MPs. Megaprostheses were most commonly used to treat periprosthetic fractures (1158 cases, 44.6%), in particular in the distal femur (859, 74.2%). Overall, complications were observed in 513 cases (19.7%). Type I (soft tissue failures) and type IV (infection) according to the Henderson classification were the most frequent (158 and 213, respectively). In conclusion, patients with severe post-traumatic deformities and/or significant bone loss who have had previous septic complications should be considered as oncologic patients, not because of the disease, but because of the limited therapeutic options available. The benefits of this treatment include relatively short operative times and immediate weight-bearing, thus making MP particularly attractive in the lower limb.
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spelling pubmed-102991212023-06-28 Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature Sambri, Andrea Parisi, Stefania Claudia Zunarelli, Renato Di Prinzio, Lorenzo Morante, Lorenzo Lonardo, Gianluca Bortoli, Marta Montanari, Andrea De Cristofaro, Roberto Fiore, Michele De Paolis, Massimiliano J Clin Med Review Modular megaprostheses (MPs) are commonly used after bone-tumor resection, but they can offer a limb salvage solution in massive bone defects. The aim of this systematic review of the Literature is to provide a comprehensive data collection concerning the use of MPs in non-oncologic cases, and to provide an overview of this topic, especially from an epidemiologic point of view. Three different databases (PubMed, Scopus, and Web of Science) were searched for relevant articles, and further references were obtained by cross-referencing. Sixty-nine studies met the inclusion criteria, reporting on cases of MP in non-oncologic cases. A total of 2598 MPs were retrieved. Among these, 1353 (52.1%) were distal femur MPs, 941 (36.2%) were proximal femur MPs, 29 (1.4%) were proximal tibia MPs and 259 (10.0%) were total femur MPs. Megaprostheses were most commonly used to treat periprosthetic fractures (1158 cases, 44.6%), in particular in the distal femur (859, 74.2%). Overall, complications were observed in 513 cases (19.7%). Type I (soft tissue failures) and type IV (infection) according to the Henderson classification were the most frequent (158 and 213, respectively). In conclusion, patients with severe post-traumatic deformities and/or significant bone loss who have had previous septic complications should be considered as oncologic patients, not because of the disease, but because of the limited therapeutic options available. The benefits of this treatment include relatively short operative times and immediate weight-bearing, thus making MP particularly attractive in the lower limb. MDPI 2023-06-20 /pmc/articles/PMC10299121/ /pubmed/37373844 http://dx.doi.org/10.3390/jcm12124151 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sambri, Andrea
Parisi, Stefania Claudia
Zunarelli, Renato
Di Prinzio, Lorenzo
Morante, Lorenzo
Lonardo, Gianluca
Bortoli, Marta
Montanari, Andrea
De Cristofaro, Roberto
Fiore, Michele
De Paolis, Massimiliano
Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature
title Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature
title_full Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature
title_fullStr Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature
title_full_unstemmed Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature
title_short Megaprosthesis in Non-Oncologic Settings—A Systematic Review of the Literature
title_sort megaprosthesis in non-oncologic settings—a systematic review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299121/
https://www.ncbi.nlm.nih.gov/pubmed/37373844
http://dx.doi.org/10.3390/jcm12124151
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