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Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up

Post-COVID-19 syndrome (PCS) has been described as ‘the pandemic after the pandemic’ with more than 65 million people worldwide being affected. The enormous range of symptoms makes both diagnosis complex and treatment difficult. In a post-COVID rehabilitation outpatient clinic, 184 patients, mostly...

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Autores principales: Steinmetz, Anke, Gross, Stefan, Lehnert, Kristin, Lücker, Petra, Friedrich, Nele, Nauck, Matthias, Bahlmann, Susanne, Fielitz, Jens, Dörr, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299126/
https://www.ncbi.nlm.nih.gov/pubmed/37373660
http://dx.doi.org/10.3390/jcm12123966
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author Steinmetz, Anke
Gross, Stefan
Lehnert, Kristin
Lücker, Petra
Friedrich, Nele
Nauck, Matthias
Bahlmann, Susanne
Fielitz, Jens
Dörr, Marcus
author_facet Steinmetz, Anke
Gross, Stefan
Lehnert, Kristin
Lücker, Petra
Friedrich, Nele
Nauck, Matthias
Bahlmann, Susanne
Fielitz, Jens
Dörr, Marcus
author_sort Steinmetz, Anke
collection PubMed
description Post-COVID-19 syndrome (PCS) has been described as ‘the pandemic after the pandemic’ with more than 65 million people worldwide being affected. The enormous range of symptoms makes both diagnosis complex and treatment difficult. In a post-COVID rehabilitation outpatient clinic, 184 patients, mostly non-hospitalized, received a comprehensive, interdisciplinary diagnostic assessment with fixed follow-up appointments. At baseline, three in four patients reported more than 10 symptoms, the most frequent symptoms were fatigue (84.9%), decreased physical capacity (83.0%), tiredness (81.1%), poor concentration (73.6%), sleeping problems (66.7%) and shortness of breath (67.3%). Abnormalities were found in the mean values of scores for fatigue (FAS = 34.3), cognition (MoCA = 25.5), psychological alterations (anxiety, depression, post-traumatic stress disorder), limitation of lung function (CAT) and severity scores for PCS (PCFS, MCRS). Clinical abnormalities were found in elevated values of heart rate, breathing rate at rest, blood pressure and NT-proBNP levels. As the frequency of the described symptoms decreases only slowly but most often significantly over the course, it is important to monitor the patients over a longer period of time. Many of them suffer from an immense symptom burden, often without pre-existing clinical correlates. Our results show a clear association with objectifiable assessments and tests as well as pronounced symptoms.
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spelling pubmed-102991262023-06-28 Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up Steinmetz, Anke Gross, Stefan Lehnert, Kristin Lücker, Petra Friedrich, Nele Nauck, Matthias Bahlmann, Susanne Fielitz, Jens Dörr, Marcus J Clin Med Article Post-COVID-19 syndrome (PCS) has been described as ‘the pandemic after the pandemic’ with more than 65 million people worldwide being affected. The enormous range of symptoms makes both diagnosis complex and treatment difficult. In a post-COVID rehabilitation outpatient clinic, 184 patients, mostly non-hospitalized, received a comprehensive, interdisciplinary diagnostic assessment with fixed follow-up appointments. At baseline, three in four patients reported more than 10 symptoms, the most frequent symptoms were fatigue (84.9%), decreased physical capacity (83.0%), tiredness (81.1%), poor concentration (73.6%), sleeping problems (66.7%) and shortness of breath (67.3%). Abnormalities were found in the mean values of scores for fatigue (FAS = 34.3), cognition (MoCA = 25.5), psychological alterations (anxiety, depression, post-traumatic stress disorder), limitation of lung function (CAT) and severity scores for PCS (PCFS, MCRS). Clinical abnormalities were found in elevated values of heart rate, breathing rate at rest, blood pressure and NT-proBNP levels. As the frequency of the described symptoms decreases only slowly but most often significantly over the course, it is important to monitor the patients over a longer period of time. Many of them suffer from an immense symptom burden, often without pre-existing clinical correlates. Our results show a clear association with objectifiable assessments and tests as well as pronounced symptoms. MDPI 2023-06-10 /pmc/articles/PMC10299126/ /pubmed/37373660 http://dx.doi.org/10.3390/jcm12123966 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Steinmetz, Anke
Gross, Stefan
Lehnert, Kristin
Lücker, Petra
Friedrich, Nele
Nauck, Matthias
Bahlmann, Susanne
Fielitz, Jens
Dörr, Marcus
Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up
title Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up
title_full Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up
title_fullStr Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up
title_full_unstemmed Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up
title_short Longitudinal Clinical Features of Post-COVID-19 Patients—Symptoms, Fatigue and Physical Function at 3- and 6-Month Follow-Up
title_sort longitudinal clinical features of post-covid-19 patients—symptoms, fatigue and physical function at 3- and 6-month follow-up
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299126/
https://www.ncbi.nlm.nih.gov/pubmed/37373660
http://dx.doi.org/10.3390/jcm12123966
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