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The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy homeostasis. Small-molecule ligands developed for the...

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Detalles Bibliográficos
Autores principales:	Ericson, Mark D., Freeman, Katie T., LaVoi, Travis M., Donow, Haley M., Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Houghten, Richard A., Haskell-Luevano, Carrie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299128/ https://www.ncbi.nlm.nih.gov/pubmed/37373293 http://dx.doi.org/10.3390/ijms241210145

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