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Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug

A novel sericin-dextran conjugate (SDC) and self-assembled microparticles has been prepared for improving solubility of atazanavir. Microparticles of SDC were assembled by the reprecipitation method. The size and morphology of SDC microparticles could be adjusted by the concentration and solvents. L...

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Detalles Bibliográficos
Autores principales: Chen, Shuqi, Feng, Xiaolong, Li, Xinwei, Liu, Miaochang, Gao, Wenxia, Miao, Qian, Wu, Huayue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299130/
https://www.ncbi.nlm.nih.gov/pubmed/37367256
http://dx.doi.org/10.3390/jfb14060292
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author Chen, Shuqi
Feng, Xiaolong
Li, Xinwei
Liu, Miaochang
Gao, Wenxia
Miao, Qian
Wu, Huayue
author_facet Chen, Shuqi
Feng, Xiaolong
Li, Xinwei
Liu, Miaochang
Gao, Wenxia
Miao, Qian
Wu, Huayue
author_sort Chen, Shuqi
collection PubMed
description A novel sericin-dextran conjugate (SDC) and self-assembled microparticles has been prepared for improving solubility of atazanavir. Microparticles of SDC were assembled by the reprecipitation method. The size and morphology of SDC microparticles could be adjusted by the concentration and solvents. Low concentration was conducive to the preparation of microspheres. Heterogeneous microspheres could be prepared in ethanol with the range of 85–390 nm, and hollow mesoporous microspheres in propanol with an average particle size of 2.5–22 µm. The aqueous solubility of atazanavir was improved to 2.22 mg/mL in buffer solutions at pH 2.0 and 1.65 mg/mL at pH 7.4 by SDC microspheres. In vitro release of atazanavir from hollow microspheres of SDC exhibited a slower release, had the lowest linear cumulative release in basic buffer (pH 8.0), and the most rapid double exponential diphase kinetic cumulative release in acid buffer (pH 2.0).
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spelling pubmed-102991302023-06-28 Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug Chen, Shuqi Feng, Xiaolong Li, Xinwei Liu, Miaochang Gao, Wenxia Miao, Qian Wu, Huayue J Funct Biomater Article A novel sericin-dextran conjugate (SDC) and self-assembled microparticles has been prepared for improving solubility of atazanavir. Microparticles of SDC were assembled by the reprecipitation method. The size and morphology of SDC microparticles could be adjusted by the concentration and solvents. Low concentration was conducive to the preparation of microspheres. Heterogeneous microspheres could be prepared in ethanol with the range of 85–390 nm, and hollow mesoporous microspheres in propanol with an average particle size of 2.5–22 µm. The aqueous solubility of atazanavir was improved to 2.22 mg/mL in buffer solutions at pH 2.0 and 1.65 mg/mL at pH 7.4 by SDC microspheres. In vitro release of atazanavir from hollow microspheres of SDC exhibited a slower release, had the lowest linear cumulative release in basic buffer (pH 8.0), and the most rapid double exponential diphase kinetic cumulative release in acid buffer (pH 2.0). MDPI 2023-05-24 /pmc/articles/PMC10299130/ /pubmed/37367256 http://dx.doi.org/10.3390/jfb14060292 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Shuqi
Feng, Xiaolong
Li, Xinwei
Liu, Miaochang
Gao, Wenxia
Miao, Qian
Wu, Huayue
Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug
title Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug
title_full Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug
title_fullStr Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug
title_full_unstemmed Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug
title_short Microparticles of Sericin-Dextran Conjugate for Improving the Solubility of Antiviral Drug
title_sort microparticles of sericin-dextran conjugate for improving the solubility of antiviral drug
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299130/
https://www.ncbi.nlm.nih.gov/pubmed/37367256
http://dx.doi.org/10.3390/jfb14060292
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