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Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2

In this paper, the influence of external terahertz electromagnetic fields with different frequencies of 4 THz, 10 THz, 15 THz, and 20 THz on the permeability of the Kv1.2 voltage-gated potassium ion channel on the nerve cell membrane was studied using the combined model of the “Constant Electric Fie...

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Autores principales: Ding, Wen, Zhao, Xiaofei, Wang, Hongguang, Wang, Yize, Liu, Yanjiang, Gong, Lirong, Lin, Shu, Liu, Chunliang, Li, Yongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299135/
https://www.ncbi.nlm.nih.gov/pubmed/37373419
http://dx.doi.org/10.3390/ijms241210271
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author Ding, Wen
Zhao, Xiaofei
Wang, Hongguang
Wang, Yize
Liu, Yanjiang
Gong, Lirong
Lin, Shu
Liu, Chunliang
Li, Yongdong
author_facet Ding, Wen
Zhao, Xiaofei
Wang, Hongguang
Wang, Yize
Liu, Yanjiang
Gong, Lirong
Lin, Shu
Liu, Chunliang
Li, Yongdong
author_sort Ding, Wen
collection PubMed
description In this paper, the influence of external terahertz electromagnetic fields with different frequencies of 4 THz, 10 THz, 15 THz, and 20 THz on the permeability of the Kv1.2 voltage-gated potassium ion channel on the nerve cell membrane was studied using the combined model of the “Constant Electric Field-Ion Imbalance” method by molecular dynamics. We found that although the applied terahertz electric field does not produce strong resonance with the –C=O groups of the conservative sequence T-V-G-Y-G amino acid residue of the selective filter (SF) of the channel, it would affect the stability of the electrostatic bond between potassium ions and the carbonyl group of T-V-G-Y-G of SF, and it would affect the stability of the hydrogen bond between water molecules and oxygen atoms of the hydroxyl group of the 374THR side chain at the SF entrance, changing the potential and occupied states of ions in the SF and the occurrence probability of the permeation mode of ions and resulting in the change in the permeability of the channel. Compared with no external electric field, when the external electric field with 15 THz frequency is applied, the lifetime of the hydrogen bond is reduced by 29%, the probability of the “soft knock on” mode is decreased by 46.9%, and the ion flux of the channel is activated by 67.7%. Our research results support the view that compared to “direct knock-on”, “soft knock-on” is a slower permeation mode.
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spelling pubmed-102991352023-06-28 Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 Ding, Wen Zhao, Xiaofei Wang, Hongguang Wang, Yize Liu, Yanjiang Gong, Lirong Lin, Shu Liu, Chunliang Li, Yongdong Int J Mol Sci Article In this paper, the influence of external terahertz electromagnetic fields with different frequencies of 4 THz, 10 THz, 15 THz, and 20 THz on the permeability of the Kv1.2 voltage-gated potassium ion channel on the nerve cell membrane was studied using the combined model of the “Constant Electric Field-Ion Imbalance” method by molecular dynamics. We found that although the applied terahertz electric field does not produce strong resonance with the –C=O groups of the conservative sequence T-V-G-Y-G amino acid residue of the selective filter (SF) of the channel, it would affect the stability of the electrostatic bond between potassium ions and the carbonyl group of T-V-G-Y-G of SF, and it would affect the stability of the hydrogen bond between water molecules and oxygen atoms of the hydroxyl group of the 374THR side chain at the SF entrance, changing the potential and occupied states of ions in the SF and the occurrence probability of the permeation mode of ions and resulting in the change in the permeability of the channel. Compared with no external electric field, when the external electric field with 15 THz frequency is applied, the lifetime of the hydrogen bond is reduced by 29%, the probability of the “soft knock on” mode is decreased by 46.9%, and the ion flux of the channel is activated by 67.7%. Our research results support the view that compared to “direct knock-on”, “soft knock-on” is a slower permeation mode. MDPI 2023-06-17 /pmc/articles/PMC10299135/ /pubmed/37373419 http://dx.doi.org/10.3390/ijms241210271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ding, Wen
Zhao, Xiaofei
Wang, Hongguang
Wang, Yize
Liu, Yanjiang
Gong, Lirong
Lin, Shu
Liu, Chunliang
Li, Yongdong
Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
title Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
title_full Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
title_fullStr Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
title_full_unstemmed Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
title_short Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
title_sort effect of terahertz electromagnetic field on the permeability of potassium channel kv1.2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299135/
https://www.ncbi.nlm.nih.gov/pubmed/37373419
http://dx.doi.org/10.3390/ijms241210271
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