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Roles of Fibroblast Growth Factors in the Axon Guidance
Fibroblast growth factors (FGFs) have been widely studied by virtue of their ability to regulate many essential cellular activities, including proliferation, survival, migration, differentiation and metabolism. Recently, these molecules have emerged as the key components in forming the intricate con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299262/ https://www.ncbi.nlm.nih.gov/pubmed/37373438 http://dx.doi.org/10.3390/ijms241210292 |
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author | Zhang, Weiyun Luo, Peiyi Liu, Xiaohan Cheng, Ruoxi Zhang, Shuxian Qian, Xiao Liu, Fang |
author_facet | Zhang, Weiyun Luo, Peiyi Liu, Xiaohan Cheng, Ruoxi Zhang, Shuxian Qian, Xiao Liu, Fang |
author_sort | Zhang, Weiyun |
collection | PubMed |
description | Fibroblast growth factors (FGFs) have been widely studied by virtue of their ability to regulate many essential cellular activities, including proliferation, survival, migration, differentiation and metabolism. Recently, these molecules have emerged as the key components in forming the intricate connections within the nervous system. FGF and FGF receptor (FGFR) signaling pathways play important roles in axon guidance as axons navigate toward their synaptic targets. This review offers a current account of axonal navigation functions performed by FGFs, which operate as chemoattractants and/or chemorepellents in different circumstances. Meanwhile, detailed mechanisms behind the axon guidance process are elaborated, which are related to intracellular signaling integration and cytoskeleton dynamics. |
format | Online Article Text |
id | pubmed-10299262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102992622023-06-28 Roles of Fibroblast Growth Factors in the Axon Guidance Zhang, Weiyun Luo, Peiyi Liu, Xiaohan Cheng, Ruoxi Zhang, Shuxian Qian, Xiao Liu, Fang Int J Mol Sci Review Fibroblast growth factors (FGFs) have been widely studied by virtue of their ability to regulate many essential cellular activities, including proliferation, survival, migration, differentiation and metabolism. Recently, these molecules have emerged as the key components in forming the intricate connections within the nervous system. FGF and FGF receptor (FGFR) signaling pathways play important roles in axon guidance as axons navigate toward their synaptic targets. This review offers a current account of axonal navigation functions performed by FGFs, which operate as chemoattractants and/or chemorepellents in different circumstances. Meanwhile, detailed mechanisms behind the axon guidance process are elaborated, which are related to intracellular signaling integration and cytoskeleton dynamics. MDPI 2023-06-18 /pmc/articles/PMC10299262/ /pubmed/37373438 http://dx.doi.org/10.3390/ijms241210292 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Weiyun Luo, Peiyi Liu, Xiaohan Cheng, Ruoxi Zhang, Shuxian Qian, Xiao Liu, Fang Roles of Fibroblast Growth Factors in the Axon Guidance |
title | Roles of Fibroblast Growth Factors in the Axon Guidance |
title_full | Roles of Fibroblast Growth Factors in the Axon Guidance |
title_fullStr | Roles of Fibroblast Growth Factors in the Axon Guidance |
title_full_unstemmed | Roles of Fibroblast Growth Factors in the Axon Guidance |
title_short | Roles of Fibroblast Growth Factors in the Axon Guidance |
title_sort | roles of fibroblast growth factors in the axon guidance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299262/ https://www.ncbi.nlm.nih.gov/pubmed/37373438 http://dx.doi.org/10.3390/ijms241210292 |
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