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Quality of Life and Kidney Function in Older Adults: Prospective Data of the SCOPE Study

A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS...

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Detalles Bibliográficos
Autores principales: Artzi-Medvedik, Rada, Kob, Robert, Di Rosa, Mirko, Lattanzio, Fabrizia, Corsonello, Andrea, Yehoshua, Ilan, Roller-Wirnsberger, Regina E., Wirnsberger, Gerhard H., Mattace-Raso, Francesco U. S., Tap, Lisanne, Gil, Pedro G., Formiga, Francesc, Moreno-González, Rafael, Kostka, Tomasz, Guligowska, Agnieszka, Ärnlöv, Johan, Carlsson, Axel C., Freiberger, Ellen, Melzer, Itshak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299288/
https://www.ncbi.nlm.nih.gov/pubmed/37373653
http://dx.doi.org/10.3390/jcm12123959
Descripción
Sumario:A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.