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The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature

This review focuses on the role of metalloproteinases in the pathogenesis of myocardial injury in various disease entities. It reveals how the expression and serum levels of metalloproteinases and their inhibitors change in many disease states. At the same time, the study offers a review of the impa...

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Autores principales: Surówka, Anna, Prowans, Piotr, Żołnierczuk, Michał, Miśkiewicz, Marek, Wawrowski, Tomasz, Skodda, Marika, Markowska, Marta, Kędzierska-Kapuza, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299316/
https://www.ncbi.nlm.nih.gov/pubmed/37373446
http://dx.doi.org/10.3390/ijms241210291
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author Surówka, Anna
Prowans, Piotr
Żołnierczuk, Michał
Miśkiewicz, Marek
Wawrowski, Tomasz
Skodda, Marika
Markowska, Marta
Kędzierska-Kapuza, Karolina
author_facet Surówka, Anna
Prowans, Piotr
Żołnierczuk, Michał
Miśkiewicz, Marek
Wawrowski, Tomasz
Skodda, Marika
Markowska, Marta
Kędzierska-Kapuza, Karolina
author_sort Surówka, Anna
collection PubMed
description This review focuses on the role of metalloproteinases in the pathogenesis of myocardial injury in various disease entities. It reveals how the expression and serum levels of metalloproteinases and their inhibitors change in many disease states. At the same time, the study offers a review of the impact of immunosuppressive treatment on this relationship. Modern immunosuppressive treatment is based mainly on the use of calcineurin inhibitors, including cyclosporine A and tacrolimus. The use of these drugs may carry a number of side effects, specifically to the cardiovascular system. The scale and degree of long-term influence on the organism remains unclear, but a significant risk of complications for transplant recipients who take immunosuppressive drugs as part of their daily treatment is to be expected. Therefore, the knowledge on this subject should be expanded and the negative effects of post-transplant therapy minimized. Immunosuppressive therapy plays an important role in the expression and activation of tissue metalloproteinases and their specific inhibitors, which leads to many tissue changes. The presented study is a collection of research results on the effects of calcineurin inhibitors on the heart, with particular emphasis placed on the participation of MMP-2 and MMP-9. It is also an analysis of the effects of specific heart diseases on myocardial remodeling through inductive or inhibitory effects on matrix metalloproteinases and their inhibitors.
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spelling pubmed-102993162023-06-28 The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature Surówka, Anna Prowans, Piotr Żołnierczuk, Michał Miśkiewicz, Marek Wawrowski, Tomasz Skodda, Marika Markowska, Marta Kędzierska-Kapuza, Karolina Int J Mol Sci Review This review focuses on the role of metalloproteinases in the pathogenesis of myocardial injury in various disease entities. It reveals how the expression and serum levels of metalloproteinases and their inhibitors change in many disease states. At the same time, the study offers a review of the impact of immunosuppressive treatment on this relationship. Modern immunosuppressive treatment is based mainly on the use of calcineurin inhibitors, including cyclosporine A and tacrolimus. The use of these drugs may carry a number of side effects, specifically to the cardiovascular system. The scale and degree of long-term influence on the organism remains unclear, but a significant risk of complications for transplant recipients who take immunosuppressive drugs as part of their daily treatment is to be expected. Therefore, the knowledge on this subject should be expanded and the negative effects of post-transplant therapy minimized. Immunosuppressive therapy plays an important role in the expression and activation of tissue metalloproteinases and their specific inhibitors, which leads to many tissue changes. The presented study is a collection of research results on the effects of calcineurin inhibitors on the heart, with particular emphasis placed on the participation of MMP-2 and MMP-9. It is also an analysis of the effects of specific heart diseases on myocardial remodeling through inductive or inhibitory effects on matrix metalloproteinases and their inhibitors. MDPI 2023-06-18 /pmc/articles/PMC10299316/ /pubmed/37373446 http://dx.doi.org/10.3390/ijms241210291 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Surówka, Anna
Prowans, Piotr
Żołnierczuk, Michał
Miśkiewicz, Marek
Wawrowski, Tomasz
Skodda, Marika
Markowska, Marta
Kędzierska-Kapuza, Karolina
The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
title The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
title_full The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
title_fullStr The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
title_full_unstemmed The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
title_short The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
title_sort effect of calcineurin inhibitors on mmps activity in heart and their side effects—a review of literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299316/
https://www.ncbi.nlm.nih.gov/pubmed/37373446
http://dx.doi.org/10.3390/ijms241210291
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