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The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness

Their widespread presence throughout the vasculature, coupled with their reactivity, and thereby to their potential to release reactive oxidative species, or to utilize their anti-oxidative capacities, has promoted much discussion of the role(s) of red blood cells (RBCs) in the progression of health...

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Detalles Bibliográficos
Autores principales: Asaro, Robert J., Profumo, Elisabetta, Buttari, Brigitta, Cabrales, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299353/
https://www.ncbi.nlm.nih.gov/pubmed/37373527
http://dx.doi.org/10.3390/ijms241210382
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author Asaro, Robert J.
Profumo, Elisabetta
Buttari, Brigitta
Cabrales, Pedro
author_facet Asaro, Robert J.
Profumo, Elisabetta
Buttari, Brigitta
Cabrales, Pedro
author_sort Asaro, Robert J.
collection PubMed
description Their widespread presence throughout the vasculature, coupled with their reactivity, and thereby to their potential to release reactive oxidative species, or to utilize their anti-oxidative capacities, has promoted much discussion of the role(s) of red blood cells (RBCs) in the progression of health or, alternatively, a wide range of disease states. Moreover, these role(s) have been linked to the development of adhesiveness and, in fact, thereby to the essential pathway to their eventual clearance, e.g., by macrophages in the spleen. These disparate roles coupled with the mechanisms involved are reviewed and given. Following an analysis, novel perspectives are provided; these perspectives can lead to novel assays for identifying the potential for RBC adhesiveness as suggested herein. We describe this paradigm, that involves RBC adhesiveness, hemolysis, and ghost formation, with examples including, inter alia, the progression of atherosclerosis and the suppression of tumor growth along with other disease states.
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spelling pubmed-102993532023-06-28 The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness Asaro, Robert J. Profumo, Elisabetta Buttari, Brigitta Cabrales, Pedro Int J Mol Sci Review Their widespread presence throughout the vasculature, coupled with their reactivity, and thereby to their potential to release reactive oxidative species, or to utilize their anti-oxidative capacities, has promoted much discussion of the role(s) of red blood cells (RBCs) in the progression of health or, alternatively, a wide range of disease states. Moreover, these role(s) have been linked to the development of adhesiveness and, in fact, thereby to the essential pathway to their eventual clearance, e.g., by macrophages in the spleen. These disparate roles coupled with the mechanisms involved are reviewed and given. Following an analysis, novel perspectives are provided; these perspectives can lead to novel assays for identifying the potential for RBC adhesiveness as suggested herein. We describe this paradigm, that involves RBC adhesiveness, hemolysis, and ghost formation, with examples including, inter alia, the progression of atherosclerosis and the suppression of tumor growth along with other disease states. MDPI 2023-06-20 /pmc/articles/PMC10299353/ /pubmed/37373527 http://dx.doi.org/10.3390/ijms241210382 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Asaro, Robert J.
Profumo, Elisabetta
Buttari, Brigitta
Cabrales, Pedro
The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
title The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
title_full The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
title_fullStr The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
title_full_unstemmed The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
title_short The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
title_sort double-edged sword of erythrocytes in health and disease via their adhesiveness
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299353/
https://www.ncbi.nlm.nih.gov/pubmed/37373527
http://dx.doi.org/10.3390/ijms241210382
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