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Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?

MPOX (monkeypox) is a zoonotic viral disease, endemic in some Central and West African countries. However, in May 2022, cases began to be reported in non-endemic countries, demonstrating community transmission. Since the beginning of the outbreak, different epidemiological and clinical behaviors hav...

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Autores principales: Estévez, Samuel, Vara, Marta, Gamo, María, Manzano, Samuel, Troya, Jesús, Botezat, Ekaterina, Jiménez, Eva, Pedrero-Tomé, Roberto, Martin, María Ángeles, de la Cueva, Pablo, Fernández, Elisa, Fernández, Beatriz, Brown, David Esteban, Palma, Elena, Simón, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299369/
https://www.ncbi.nlm.nih.gov/pubmed/37373818
http://dx.doi.org/10.3390/jcm12124124
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author Estévez, Samuel
Vara, Marta
Gamo, María
Manzano, Samuel
Troya, Jesús
Botezat, Ekaterina
Jiménez, Eva
Pedrero-Tomé, Roberto
Martin, María Ángeles
de la Cueva, Pablo
Fernández, Elisa
Fernández, Beatriz
Brown, David Esteban
Palma, Elena
Simón, Ana
author_facet Estévez, Samuel
Vara, Marta
Gamo, María
Manzano, Samuel
Troya, Jesús
Botezat, Ekaterina
Jiménez, Eva
Pedrero-Tomé, Roberto
Martin, María Ángeles
de la Cueva, Pablo
Fernández, Elisa
Fernández, Beatriz
Brown, David Esteban
Palma, Elena
Simón, Ana
author_sort Estévez, Samuel
collection PubMed
description MPOX (monkeypox) is a zoonotic viral disease, endemic in some Central and West African countries. However, in May 2022, cases began to be reported in non-endemic countries, demonstrating community transmission. Since the beginning of the outbreak, different epidemiological and clinical behaviors have been observed. We conducted an observational study at a secondary hospital in Madrid to characterize suspected and confirmed cases of MPOX epidemiologically and clinically. Besides the general descriptive analysis, we compared data between HIV-positive and HIV-negative subjects; 133 patients were evaluated with suspected MPOX, of which 100 were confirmed. Regarding positive cases, 71.0% were HIV positive, and 99.0% were men with a mean age of 33. In the previous year, 97.6% reported having sex with men, 53.6% used apps for sexual encounters, 22.9% practiced chemsex, and 16.7% went to saunas. Inguinal adenopathies were significantly higher in MPOX cases (54.0% vs. 12.1%, p < 0.001), as the involvement of genital and perianal area (57.0% vs. 27.3% and 17.0% vs. 1.0%, p = 0.006 and p = 0.082 respectively). Pustules were the most common skin lesion (45.0%). In HIV-positive cases, only 6.9% had a detectable viral load, and the mean CD4 count was 607.0/mm(3). No significant differences were observed in the disease course, except for a greater tendency towards the appearance of perianal lesions. In conclusion, the MPOX 2022 outbreak in our area has been related to sexual intercourse among MSM, with no severe clinical cases nor apparent differences in HIV and non-HIV patients.
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spelling pubmed-102993692023-06-28 Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role? Estévez, Samuel Vara, Marta Gamo, María Manzano, Samuel Troya, Jesús Botezat, Ekaterina Jiménez, Eva Pedrero-Tomé, Roberto Martin, María Ángeles de la Cueva, Pablo Fernández, Elisa Fernández, Beatriz Brown, David Esteban Palma, Elena Simón, Ana J Clin Med Article MPOX (monkeypox) is a zoonotic viral disease, endemic in some Central and West African countries. However, in May 2022, cases began to be reported in non-endemic countries, demonstrating community transmission. Since the beginning of the outbreak, different epidemiological and clinical behaviors have been observed. We conducted an observational study at a secondary hospital in Madrid to characterize suspected and confirmed cases of MPOX epidemiologically and clinically. Besides the general descriptive analysis, we compared data between HIV-positive and HIV-negative subjects; 133 patients were evaluated with suspected MPOX, of which 100 were confirmed. Regarding positive cases, 71.0% were HIV positive, and 99.0% were men with a mean age of 33. In the previous year, 97.6% reported having sex with men, 53.6% used apps for sexual encounters, 22.9% practiced chemsex, and 16.7% went to saunas. Inguinal adenopathies were significantly higher in MPOX cases (54.0% vs. 12.1%, p < 0.001), as the involvement of genital and perianal area (57.0% vs. 27.3% and 17.0% vs. 1.0%, p = 0.006 and p = 0.082 respectively). Pustules were the most common skin lesion (45.0%). In HIV-positive cases, only 6.9% had a detectable viral load, and the mean CD4 count was 607.0/mm(3). No significant differences were observed in the disease course, except for a greater tendency towards the appearance of perianal lesions. In conclusion, the MPOX 2022 outbreak in our area has been related to sexual intercourse among MSM, with no severe clinical cases nor apparent differences in HIV and non-HIV patients. MDPI 2023-06-18 /pmc/articles/PMC10299369/ /pubmed/37373818 http://dx.doi.org/10.3390/jcm12124124 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estévez, Samuel
Vara, Marta
Gamo, María
Manzano, Samuel
Troya, Jesús
Botezat, Ekaterina
Jiménez, Eva
Pedrero-Tomé, Roberto
Martin, María Ángeles
de la Cueva, Pablo
Fernández, Elisa
Fernández, Beatriz
Brown, David Esteban
Palma, Elena
Simón, Ana
Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?
title Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?
title_full Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?
title_fullStr Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?
title_full_unstemmed Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?
title_short Epidemiological and Clinical Characteristics of Patients Admitted to a Secondary Hospital with Suspected MPOX Virus Infection: Is HIV Playing a Role?
title_sort epidemiological and clinical characteristics of patients admitted to a secondary hospital with suspected mpox virus infection: is hiv playing a role?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299369/
https://www.ncbi.nlm.nih.gov/pubmed/37373818
http://dx.doi.org/10.3390/jcm12124124
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