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Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study

Background and aim: Physical activity (PA) can modulate the immune response, but its impact on infectious disease severity is unknown. We assess if the PA level impacts the severity of COVID-19. Methods: Prospective, cohort study for adults hospitalized due to COVID-19, who filled out the Internatio...

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Autores principales: Sutkowska, Edyta, Stanek, Agata, Madziarska, Katarzyna, Jakubiak, Grzegorz K., Sokołowski, Janusz, Madziarski, Marcin, Sutkowska-Stępień, Karolina, Biernat, Karolina, Mazurek, Justyna, Borowkow-Bulek, Adrianna, Czyżewski, Jakub, Wilk, Gabriela, Jagasyk, Arkadiusz, Marciniak, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299429/
https://www.ncbi.nlm.nih.gov/pubmed/37373739
http://dx.doi.org/10.3390/jcm12124046
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author Sutkowska, Edyta
Stanek, Agata
Madziarska, Katarzyna
Jakubiak, Grzegorz K.
Sokołowski, Janusz
Madziarski, Marcin
Sutkowska-Stępień, Karolina
Biernat, Karolina
Mazurek, Justyna
Borowkow-Bulek, Adrianna
Czyżewski, Jakub
Wilk, Gabriela
Jagasyk, Arkadiusz
Marciniak, Dominik
author_facet Sutkowska, Edyta
Stanek, Agata
Madziarska, Katarzyna
Jakubiak, Grzegorz K.
Sokołowski, Janusz
Madziarski, Marcin
Sutkowska-Stępień, Karolina
Biernat, Karolina
Mazurek, Justyna
Borowkow-Bulek, Adrianna
Czyżewski, Jakub
Wilk, Gabriela
Jagasyk, Arkadiusz
Marciniak, Dominik
author_sort Sutkowska, Edyta
collection PubMed
description Background and aim: Physical activity (PA) can modulate the immune response, but its impact on infectious disease severity is unknown. We assess if the PA level impacts the severity of COVID-19. Methods: Prospective, cohort study for adults hospitalized due to COVID-19, who filled out the International Physical Activity Questionnaire (IPAQ). Disease severity was expressed as death, transfer to intensive care unit (ICU), oxygen therapy (OxTh), hospitalization length, complications, C-reactive protein, and procalcitonin level. Results: Out of 326 individuals, 131 (57; 43.51% women) were analyzed: age: median—70; range: 20–95; BMI: mean—27.18 kg/m²; and SD: ±4.77. During hospitalization: 117 (83.31%) individuals recovered, nine (6.87%) were transferred to ICU, five (3.82%) died, and 83 (63.36%) needed OxTh. The median for the hospital stay was 11 (range: 3–49) for discharged patients, and mean hospitalization length was 14 (SD: ±5.8312) for deaths and 14.22 days (SD: ±6.92) for ICU-transferred patients. The median for MET-min/week was 660 (range: 0–19,200). Sufficient or high PA was found in recovered patients but insufficient PA was observed in dead or ICU-transferred patients (p = 0.03). The individuals with poor PA had a higher risk of death (HR = 2.63; ±95%CI 0.58–11.93; p = 0.037). OxTh was used more often in the less active individuals (p = 0.03). The principal component analysis confirmed a relationship between insufficient PA and an unfavorable course of the disease. Conclusion: A higher level of PA is associated with a milder course of COVID-19.
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spelling pubmed-102994292023-06-28 Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study Sutkowska, Edyta Stanek, Agata Madziarska, Katarzyna Jakubiak, Grzegorz K. Sokołowski, Janusz Madziarski, Marcin Sutkowska-Stępień, Karolina Biernat, Karolina Mazurek, Justyna Borowkow-Bulek, Adrianna Czyżewski, Jakub Wilk, Gabriela Jagasyk, Arkadiusz Marciniak, Dominik J Clin Med Article Background and aim: Physical activity (PA) can modulate the immune response, but its impact on infectious disease severity is unknown. We assess if the PA level impacts the severity of COVID-19. Methods: Prospective, cohort study for adults hospitalized due to COVID-19, who filled out the International Physical Activity Questionnaire (IPAQ). Disease severity was expressed as death, transfer to intensive care unit (ICU), oxygen therapy (OxTh), hospitalization length, complications, C-reactive protein, and procalcitonin level. Results: Out of 326 individuals, 131 (57; 43.51% women) were analyzed: age: median—70; range: 20–95; BMI: mean—27.18 kg/m²; and SD: ±4.77. During hospitalization: 117 (83.31%) individuals recovered, nine (6.87%) were transferred to ICU, five (3.82%) died, and 83 (63.36%) needed OxTh. The median for the hospital stay was 11 (range: 3–49) for discharged patients, and mean hospitalization length was 14 (SD: ±5.8312) for deaths and 14.22 days (SD: ±6.92) for ICU-transferred patients. The median for MET-min/week was 660 (range: 0–19,200). Sufficient or high PA was found in recovered patients but insufficient PA was observed in dead or ICU-transferred patients (p = 0.03). The individuals with poor PA had a higher risk of death (HR = 2.63; ±95%CI 0.58–11.93; p = 0.037). OxTh was used more often in the less active individuals (p = 0.03). The principal component analysis confirmed a relationship between insufficient PA and an unfavorable course of the disease. Conclusion: A higher level of PA is associated with a milder course of COVID-19. MDPI 2023-06-14 /pmc/articles/PMC10299429/ /pubmed/37373739 http://dx.doi.org/10.3390/jcm12124046 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sutkowska, Edyta
Stanek, Agata
Madziarska, Katarzyna
Jakubiak, Grzegorz K.
Sokołowski, Janusz
Madziarski, Marcin
Sutkowska-Stępień, Karolina
Biernat, Karolina
Mazurek, Justyna
Borowkow-Bulek, Adrianna
Czyżewski, Jakub
Wilk, Gabriela
Jagasyk, Arkadiusz
Marciniak, Dominik
Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
title Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
title_full Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
title_fullStr Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
title_full_unstemmed Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
title_short Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
title_sort physical activity modifies the severity of covid-19 in hospitalized patients—observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299429/
https://www.ncbi.nlm.nih.gov/pubmed/37373739
http://dx.doi.org/10.3390/jcm12124046
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