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Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion †
Critically ill patients with sepsis often require packed cell transfusions (PCT). However, PCT may affect white blood cell (WBC) counts. We conducted a population-based retrospective cohort study to trace changes in WBC count following PCT in critically ill patients with sepsis. We included 962 pati...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299447/ https://www.ncbi.nlm.nih.gov/pubmed/37373614 http://dx.doi.org/10.3390/jcm12123912 |
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author | Klein, Moti Hassan, Lior Katz, Rivka Abuhasira, Ran Boyko, Matthew Gabay, Ohad Frank, Dmitry Binyamin, Yair Novack, Victor Frenkel, Amit |
author_facet | Klein, Moti Hassan, Lior Katz, Rivka Abuhasira, Ran Boyko, Matthew Gabay, Ohad Frank, Dmitry Binyamin, Yair Novack, Victor Frenkel, Amit |
author_sort | Klein, Moti |
collection | PubMed |
description | Critically ill patients with sepsis often require packed cell transfusions (PCT). However, PCT may affect white blood cell (WBC) counts. We conducted a population-based retrospective cohort study to trace changes in WBC count following PCT in critically ill patients with sepsis. We included 962 patients who received one unit of PCT while hospitalized in a general intensive care unit, and 994 matched patients who did not receive PCT. We calculated the mean values of WBC count for the 24 h before and 24 h after PCT. Multivariable analyses using a mixed linear regression model were performed. The mean WBC count decreased in both groups, but more in the non-PCT group (from 13.9 × 10(9)/L to 12.2 × 10(9)/L versus 13.9 × 10(9)/L to 12.8 × 10(9)/L). A linear regression model showed a mean decrease of 0.45 × 10(9)/L in WBC count over the 24 h following the start of PCT. Every 1.0 × 10(9)/L increase in the WBC count prior to PCT administration showed a corresponding decrease of 0.19 × 10(9)/L in the final WBC count. In conclusion, among critically ill patients with sepsis, PCT causes only mild and clinically non-prominent changes in WBC count. |
format | Online Article Text |
id | pubmed-10299447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102994472023-06-28 Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † Klein, Moti Hassan, Lior Katz, Rivka Abuhasira, Ran Boyko, Matthew Gabay, Ohad Frank, Dmitry Binyamin, Yair Novack, Victor Frenkel, Amit J Clin Med Article Critically ill patients with sepsis often require packed cell transfusions (PCT). However, PCT may affect white blood cell (WBC) counts. We conducted a population-based retrospective cohort study to trace changes in WBC count following PCT in critically ill patients with sepsis. We included 962 patients who received one unit of PCT while hospitalized in a general intensive care unit, and 994 matched patients who did not receive PCT. We calculated the mean values of WBC count for the 24 h before and 24 h after PCT. Multivariable analyses using a mixed linear regression model were performed. The mean WBC count decreased in both groups, but more in the non-PCT group (from 13.9 × 10(9)/L to 12.2 × 10(9)/L versus 13.9 × 10(9)/L to 12.8 × 10(9)/L). A linear regression model showed a mean decrease of 0.45 × 10(9)/L in WBC count over the 24 h following the start of PCT. Every 1.0 × 10(9)/L increase in the WBC count prior to PCT administration showed a corresponding decrease of 0.19 × 10(9)/L in the final WBC count. In conclusion, among critically ill patients with sepsis, PCT causes only mild and clinically non-prominent changes in WBC count. MDPI 2023-06-08 /pmc/articles/PMC10299447/ /pubmed/37373614 http://dx.doi.org/10.3390/jcm12123912 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Klein, Moti Hassan, Lior Katz, Rivka Abuhasira, Ran Boyko, Matthew Gabay, Ohad Frank, Dmitry Binyamin, Yair Novack, Victor Frenkel, Amit Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † |
title | Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † |
title_full | Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † |
title_fullStr | Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † |
title_full_unstemmed | Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † |
title_short | Challenging the Interpretation of White Blood Cell Counts in Patients with Sepsis Following Packed Cell Transfusion † |
title_sort | challenging the interpretation of white blood cell counts in patients with sepsis following packed cell transfusion † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299447/ https://www.ncbi.nlm.nih.gov/pubmed/37373614 http://dx.doi.org/10.3390/jcm12123912 |
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