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Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy

Percutaneous kidney biopsy is essential for diagnosing various kidney diseases. However, insufficient glomerular yield leads to misdiagnosis, a critical problem. We retrospectively investigated the risk of insufficient glomerular yield in percutaneous kidney biopsies. We included 236 patients who un...

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Autores principales: Torigoe, Kenta, Sakamoto, Ryosuke, Abe, Shinichi, Muta, Kumiko, Mukae, Hiroshi, Nishino, Tomoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299488/
https://www.ncbi.nlm.nih.gov/pubmed/37373572
http://dx.doi.org/10.3390/jcm12123877
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author Torigoe, Kenta
Sakamoto, Ryosuke
Abe, Shinichi
Muta, Kumiko
Mukae, Hiroshi
Nishino, Tomoya
author_facet Torigoe, Kenta
Sakamoto, Ryosuke
Abe, Shinichi
Muta, Kumiko
Mukae, Hiroshi
Nishino, Tomoya
author_sort Torigoe, Kenta
collection PubMed
description Percutaneous kidney biopsy is essential for diagnosing various kidney diseases. However, insufficient glomerular yield leads to misdiagnosis, a critical problem. We retrospectively investigated the risk of insufficient glomerular yield in percutaneous kidney biopsies. We included 236 patients who underwent percutaneous kidney biopsies between April 2017 and September 2020. We retrospectively analyzed the relationship between glomerular yield and patient characteristics. After the biopsy, 31 patients produced insufficient glomerular yields (cases with yielded glomeruli <10). Glomerular yield correlated negatively with hypertension (β = −0.13, p = 0.04), and positively with glomerular density (β = 0.59, p < 0.0001) and the volume of the biopsy core (number of punctures, number of biopsy cores, total length of biopsy core, length of core collected by one puncture, and cortical length). Patients yielding <10 glomeruli had lower glomerular densities (14.4 ± 1.6 vs. 22.9 ± 0.6/cm; p < 0.0001). These results suggest that glomerular density is crucial to glomerular yield. Furthermore, glomerular density was negatively correlated with hypertension, diabetes, and age. Hypertension was independently associated with low glomerular density (β = −0.16, p = 0.02). Thus, the glomerular yield was associated with glomerular density and biopsy core length, and hypertension might be related to glomerular yield via low glomerular density.
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spelling pubmed-102994882023-06-28 Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy Torigoe, Kenta Sakamoto, Ryosuke Abe, Shinichi Muta, Kumiko Mukae, Hiroshi Nishino, Tomoya J Clin Med Article Percutaneous kidney biopsy is essential for diagnosing various kidney diseases. However, insufficient glomerular yield leads to misdiagnosis, a critical problem. We retrospectively investigated the risk of insufficient glomerular yield in percutaneous kidney biopsies. We included 236 patients who underwent percutaneous kidney biopsies between April 2017 and September 2020. We retrospectively analyzed the relationship between glomerular yield and patient characteristics. After the biopsy, 31 patients produced insufficient glomerular yields (cases with yielded glomeruli <10). Glomerular yield correlated negatively with hypertension (β = −0.13, p = 0.04), and positively with glomerular density (β = 0.59, p < 0.0001) and the volume of the biopsy core (number of punctures, number of biopsy cores, total length of biopsy core, length of core collected by one puncture, and cortical length). Patients yielding <10 glomeruli had lower glomerular densities (14.4 ± 1.6 vs. 22.9 ± 0.6/cm; p < 0.0001). These results suggest that glomerular density is crucial to glomerular yield. Furthermore, glomerular density was negatively correlated with hypertension, diabetes, and age. Hypertension was independently associated with low glomerular density (β = −0.16, p = 0.02). Thus, the glomerular yield was associated with glomerular density and biopsy core length, and hypertension might be related to glomerular yield via low glomerular density. MDPI 2023-06-06 /pmc/articles/PMC10299488/ /pubmed/37373572 http://dx.doi.org/10.3390/jcm12123877 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torigoe, Kenta
Sakamoto, Ryosuke
Abe, Shinichi
Muta, Kumiko
Mukae, Hiroshi
Nishino, Tomoya
Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy
title Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy
title_full Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy
title_fullStr Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy
title_full_unstemmed Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy
title_short Factors Associated with Glomerular Yield in Percutaneous Kidney Biopsy
title_sort factors associated with glomerular yield in percutaneous kidney biopsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299488/
https://www.ncbi.nlm.nih.gov/pubmed/37373572
http://dx.doi.org/10.3390/jcm12123877
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