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Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives
The global prevalence of overweight and obesity has dramatically increased in the last few decades, with a significant socioeconomic burden. In this narrative review, we include clinical studies aiming to provide the necessary knowledge on the role of the gut microbiota in the development of diabeti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299495/ https://www.ncbi.nlm.nih.gov/pubmed/37373556 http://dx.doi.org/10.3390/ijms241210409 |
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author | Ciarambino, Tiziana Crispino, Pietro Leto, Gaetano Minervini, Giovanni Para, Ombretta Giordano, Mauro |
author_facet | Ciarambino, Tiziana Crispino, Pietro Leto, Gaetano Minervini, Giovanni Para, Ombretta Giordano, Mauro |
author_sort | Ciarambino, Tiziana |
collection | PubMed |
description | The global prevalence of overweight and obesity has dramatically increased in the last few decades, with a significant socioeconomic burden. In this narrative review, we include clinical studies aiming to provide the necessary knowledge on the role of the gut microbiota in the development of diabetic pathology and glucose-metabolism-related disorders. In particular, the role of a certain microbial composition of the fermentative type seems to emerge without a specific link to the development in certain subjects of obesity and the chronic inflammation of the adipose tissues, which underlies the pathological development of all the diseases related to glucose metabolism and metabolic syndrome. The gut microbiota plays an important role in glucose tolerance. Conclusion. New knowledge and new information is presented on the development of individualized therapies for patients affected by all the conditions related to reduced glucose tolerance and insulin resistance. |
format | Online Article Text |
id | pubmed-10299495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102994952023-06-28 Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives Ciarambino, Tiziana Crispino, Pietro Leto, Gaetano Minervini, Giovanni Para, Ombretta Giordano, Mauro Int J Mol Sci Review The global prevalence of overweight and obesity has dramatically increased in the last few decades, with a significant socioeconomic burden. In this narrative review, we include clinical studies aiming to provide the necessary knowledge on the role of the gut microbiota in the development of diabetic pathology and glucose-metabolism-related disorders. In particular, the role of a certain microbial composition of the fermentative type seems to emerge without a specific link to the development in certain subjects of obesity and the chronic inflammation of the adipose tissues, which underlies the pathological development of all the diseases related to glucose metabolism and metabolic syndrome. The gut microbiota plays an important role in glucose tolerance. Conclusion. New knowledge and new information is presented on the development of individualized therapies for patients affected by all the conditions related to reduced glucose tolerance and insulin resistance. MDPI 2023-06-20 /pmc/articles/PMC10299495/ /pubmed/37373556 http://dx.doi.org/10.3390/ijms241210409 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ciarambino, Tiziana Crispino, Pietro Leto, Gaetano Minervini, Giovanni Para, Ombretta Giordano, Mauro Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives |
title | Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives |
title_full | Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives |
title_fullStr | Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives |
title_full_unstemmed | Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives |
title_short | Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives |
title_sort | microbiota and glucidic metabolism: a link with multiple aspects and perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299495/ https://www.ncbi.nlm.nih.gov/pubmed/37373556 http://dx.doi.org/10.3390/ijms241210409 |
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