Cargando…

Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities

Preclinical biomedical models are a fundamental tool to improve the knowledge and management of diseases, particularly in diabetes mellitus (DM) since, currently, the pathophysiological and molecular mechanisms involved in its development are not fully clarified, and there is no treatment to cure DM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martín-Carro, Beatriz, Donate-Correa, Javier, Fernández-Villabrille, Sara, Martín-Vírgala, Julia, Panizo, Sara, Carrillo-López, Natalia, Martínez-Arias, Laura, Navarro-González, Juan F., Naves-Díaz, Manuel, Fernández-Martín, José L., Alonso-Montes, Cristina, Cannata-Andía, Jorge B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299511/ https://www.ncbi.nlm.nih.gov/pubmed/37373455 http://dx.doi.org/10.3390/ijms241210309

Ejemplares similares

Phosphorus May Induce Phenotypic Transdifferentiation of Vascular Smooth Muscle Cells through the Reduction of microRNA-145
por: Fernández-Villabrille, Sara, et al.
Publicado: (2023)

Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes
por: Martín-Carro, Beatriz, et al.
Publicado: (2023)

MicroRNA-145 and microRNA-486 are potential serum biomarkers for vascular calcification
por: Fernández-Villabrille, Sara, et al.
Publicado: (2023)

Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
por: Panizo, Sara, et al.
Publicado: (2021)

Serum and Urinary Soluble α-Klotho as Markers of Kidney and Vascular Impairment
por: Martín-Vírgala, Julia, et al.
Publicado: (2023)

Redox Metabolism and Vascular Calcification in Chronic Kidney Disease
por: Carrillo-López, Natalia, et al.
Publicado: (2023)

Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure
por: Martínez-Arias, Laura, et al.
Publicado: (2023)

Mineral and bone metabolism markers and mortality in diabetic patients on haemodialysis
por: Martín-Carro, Beatriz, et al.
Publicado: (2023)

Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
por: Cannata-Andía, Jorge B., et al.
Publicado: (2021)

Vitamin D Treatment Prevents Uremia-Induced Reductions in Aortic microRNA-145 Attenuating Osteogenic Differentiation despite Hyperphosphatemia
por: Carrillo-López, Natalia, et al.
Publicado: (2022)

Novel Immune Cell Subsets Exhibit Different Associations With Vascular Outcomes in Chronic Kidney Disease Patients—Identifying Potential Biomarkers
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2021)

Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease
por: Donate-Correa, Javier, et al.
Publicado: (2022)

A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: the COVID-VIT-D—a randomised multicentre international clinical trial
por: Cannata-Andía, Jorge B., et al.
Publicado: (2022)

Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Slow RNAPII Transcription Elongation Rate, Low Levels of RNAPII Pausing, and Elevated Histone H1 Content at Promoters Associate with Higher m6A Deposition on Nascent mRNAs
por: Gallego, Alicia, et al.
Publicado: (2022)

Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition
por: Arcidiacono, Maria Vittoria, et al.
Publicado: (2019)

Vascular calcifications, vertebral fractures and mortality in haemodialysis patients
por: Rodríguez-García, Minerva, et al.
Publicado: (2009)

The hypercalcaemia of CYP24A1 inactivation: new ways to improve diagnosis and treatment
por: Dusso, Adriana S., et al.
Publicado: (2015)

Inflammatory Cytokines in Diabetic Nephropathy
por: Donate-Correa, Javier, et al.
Publicado: (2015)

The Pathophysiology of Secondary Hyperparathyroidism and the Consequences of Uncontrolled Mineral Metabolism in Chronic Kidney Disease: The Role of COSMOS
por: Cannata-Andía, Jorge B., et al.
Publicado: (2008)

Platelet-rich plasma (PRP) in chronic epicondylitis: study protocol for a randomized controlled trial
por: Martin, Jose I, et al.
Publicado: (2013)

Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2019)

Updated programme for harmonization of training in nephrology in the European Union
por: Lappin, David W.P., et al.
Publicado: (2013)

Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease
por: Donate‐Correa, Javier, et al.
Publicado: (2015)

Extracellular water/total body water ratio as predictor of mortality in hemodialysis patients
por: Pérez-Morales, Rosa, et al.
Publicado: (2021)

FGF23 and Klotho Levels are Independently Associated with Diabetic Foot Syndrome in Type 2 Diabetes Mellitus
por: Donate-Correa, Javier, et al.
Publicado: (2019)

Opportunities and Limitations of Mobile Neuroimaging Technologies in Educational Neuroscience
por: Janssen, Tieme W.P., et al.
Publicado: (2021)

Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Pathophysiological Implications of Imbalances in Fibroblast Growth Factor 23 in the Development of Diabetes
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations
por: Martín-Sabroso, Cristina, et al.
Publicado: (2021)

A post pandemic roadmap toward remote assessment for neuromuscular disorders: limitations and opportunities
por: Montes, Jacqueline, et al.
Publicado: (2022)

Optimizing diabetes mellitus care to improve COVID-19 outcomes in resource-limited settings in Africa
por: Kyazze, Andrew Peter, et al.
Publicado: (2021)

Self-sustained enzymatic cascade for the production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfural
por: Carro, Juan, et al.
Publicado: (2018)

Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease
por: Donate-Correa, J., et al.
Publicado: (2014)

Dynamics & Spectroscopy with Neutrons—Recent Developments & Emerging Opportunities
por: Drużbicki, Kacper, et al.
Publicado: (2021)

Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
por: Fernández-Justel, José Miguel, et al.
Publicado: (2022)

Newspaper Coverage and Framing of Bats, and Their Impact on Readership Engagement
por: López-Baucells, Adrià, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k4cc55af6i2d3kln8qrhn2q2gc