Cargando…

Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers

Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s enviro...

Descripción completa

Detalles Bibliográficos
Autores principales: Grafanaki, Katerina, Antonatos, Charalabos, Maniatis, Alexandros, Petropoulou, Antonia, Vryzaki, Eleftheria, Vasilopoulos, Yiannis, Georgiou, Sophia, Gregoriou, Stamatis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299550/
https://www.ncbi.nlm.nih.gov/pubmed/37373692
http://dx.doi.org/10.3390/jcm12124000
_version_ 1785064392056897536
author Grafanaki, Katerina
Antonatos, Charalabos
Maniatis, Alexandros
Petropoulou, Antonia
Vryzaki, Eleftheria
Vasilopoulos, Yiannis
Georgiou, Sophia
Gregoriou, Stamatis
author_facet Grafanaki, Katerina
Antonatos, Charalabos
Maniatis, Alexandros
Petropoulou, Antonia
Vryzaki, Eleftheria
Vasilopoulos, Yiannis
Georgiou, Sophia
Gregoriou, Stamatis
author_sort Grafanaki, Katerina
collection PubMed
description Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s environmental risk factors that contribute to AD. The periods of pregnancy, infancy, and teenage years are recognized as crucial stages in the formation of AD, where the exposome leads to enduring impacts on the immune system. However, research is now focusing on the interactions between intrinsic pathways that are modulated by the extrinsic exposome, including genetic variation, epigenetic modifications, and signals, such as diet, stress, and microbiome interactions. As a result, immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders.
format Online
Article
Text
id pubmed-10299550
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102995502023-06-28 Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers Grafanaki, Katerina Antonatos, Charalabos Maniatis, Alexandros Petropoulou, Antonia Vryzaki, Eleftheria Vasilopoulos, Yiannis Georgiou, Sophia Gregoriou, Stamatis J Clin Med Review Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s environmental risk factors that contribute to AD. The periods of pregnancy, infancy, and teenage years are recognized as crucial stages in the formation of AD, where the exposome leads to enduring impacts on the immune system. However, research is now focusing on the interactions between intrinsic pathways that are modulated by the extrinsic exposome, including genetic variation, epigenetic modifications, and signals, such as diet, stress, and microbiome interactions. As a result, immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders. MDPI 2023-06-12 /pmc/articles/PMC10299550/ /pubmed/37373692 http://dx.doi.org/10.3390/jcm12124000 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grafanaki, Katerina
Antonatos, Charalabos
Maniatis, Alexandros
Petropoulou, Antonia
Vryzaki, Eleftheria
Vasilopoulos, Yiannis
Georgiou, Sophia
Gregoriou, Stamatis
Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
title Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
title_full Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
title_fullStr Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
title_full_unstemmed Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
title_short Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
title_sort intrinsic effects of exposome in atopic dermatitis: genomics, epigenomics and regulatory layers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299550/
https://www.ncbi.nlm.nih.gov/pubmed/37373692
http://dx.doi.org/10.3390/jcm12124000
work_keys_str_mv AT grafanakikaterina intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT antonatoscharalabos intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT maniatisalexandros intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT petropoulouantonia intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT vryzakieleftheria intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT vasilopoulosyiannis intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT georgiousophia intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers
AT gregorioustamatis intrinsiceffectsofexposomeinatopicdermatitisgenomicsepigenomicsandregulatorylayers