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Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s enviro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299550/ https://www.ncbi.nlm.nih.gov/pubmed/37373692 http://dx.doi.org/10.3390/jcm12124000 |
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author | Grafanaki, Katerina Antonatos, Charalabos Maniatis, Alexandros Petropoulou, Antonia Vryzaki, Eleftheria Vasilopoulos, Yiannis Georgiou, Sophia Gregoriou, Stamatis |
author_facet | Grafanaki, Katerina Antonatos, Charalabos Maniatis, Alexandros Petropoulou, Antonia Vryzaki, Eleftheria Vasilopoulos, Yiannis Georgiou, Sophia Gregoriou, Stamatis |
author_sort | Grafanaki, Katerina |
collection | PubMed |
description | Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s environmental risk factors that contribute to AD. The periods of pregnancy, infancy, and teenage years are recognized as crucial stages in the formation of AD, where the exposome leads to enduring impacts on the immune system. However, research is now focusing on the interactions between intrinsic pathways that are modulated by the extrinsic exposome, including genetic variation, epigenetic modifications, and signals, such as diet, stress, and microbiome interactions. As a result, immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders. |
format | Online Article Text |
id | pubmed-10299550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102995502023-06-28 Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers Grafanaki, Katerina Antonatos, Charalabos Maniatis, Alexandros Petropoulou, Antonia Vryzaki, Eleftheria Vasilopoulos, Yiannis Georgiou, Sophia Gregoriou, Stamatis J Clin Med Review Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s environmental risk factors that contribute to AD. The periods of pregnancy, infancy, and teenage years are recognized as crucial stages in the formation of AD, where the exposome leads to enduring impacts on the immune system. However, research is now focusing on the interactions between intrinsic pathways that are modulated by the extrinsic exposome, including genetic variation, epigenetic modifications, and signals, such as diet, stress, and microbiome interactions. As a result, immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders. MDPI 2023-06-12 /pmc/articles/PMC10299550/ /pubmed/37373692 http://dx.doi.org/10.3390/jcm12124000 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Grafanaki, Katerina Antonatos, Charalabos Maniatis, Alexandros Petropoulou, Antonia Vryzaki, Eleftheria Vasilopoulos, Yiannis Georgiou, Sophia Gregoriou, Stamatis Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
title | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
title_full | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
title_fullStr | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
title_full_unstemmed | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
title_short | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
title_sort | intrinsic effects of exposome in atopic dermatitis: genomics, epigenomics and regulatory layers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299550/ https://www.ncbi.nlm.nih.gov/pubmed/37373692 http://dx.doi.org/10.3390/jcm12124000 |
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