Cargando…

Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy

Background: Left atrial (LA) function is crucial for assessing left ventricular filling in various cardiovascular conditions. Cardiac Amyloidosis (CA) is characterized by atrial myopathy and LA function impairment, with diastolic dysfunction up to restrictive filling pattern, leading to progressive...

Descripción completa

Detalles Bibliográficos
Autores principales: Monte, Ines Paola, Faro, Denise Cristiana, Trimarchi, Giancarlo, de Gaetano, Fabrizio, Campisi, Mariapaola, Losi, Valentina, Teresi, Lucio, Di Bella, Gianluca, Tamburino, Corrado, de Gregorio, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299603/
https://www.ncbi.nlm.nih.gov/pubmed/37367426
http://dx.doi.org/10.3390/jcdd10060261
_version_ 1785064405191360512
author Monte, Ines Paola
Faro, Denise Cristiana
Trimarchi, Giancarlo
de Gaetano, Fabrizio
Campisi, Mariapaola
Losi, Valentina
Teresi, Lucio
Di Bella, Gianluca
Tamburino, Corrado
de Gregorio, Cesare
author_facet Monte, Ines Paola
Faro, Denise Cristiana
Trimarchi, Giancarlo
de Gaetano, Fabrizio
Campisi, Mariapaola
Losi, Valentina
Teresi, Lucio
Di Bella, Gianluca
Tamburino, Corrado
de Gregorio, Cesare
author_sort Monte, Ines Paola
collection PubMed
description Background: Left atrial (LA) function is crucial for assessing left ventricular filling in various cardiovascular conditions. Cardiac Amyloidosis (CA) is characterized by atrial myopathy and LA function impairment, with diastolic dysfunction up to restrictive filling pattern, leading to progressive heart failure and arrhythmias. This study evaluates LA function and deformation using speckle tracking echocardiography (STE) in patients with CA compared to a cohort of patients with sarcomeric Hypertrophic Cardiomyopathy (HCM) and a control group. Methods: We conducted a retrospective, observational study (from January 2019 to December 2022) including a total of 100 patients: 33 with ATTR-CA, 34 with HCMs, and 33 controls. Clinical evaluation, electrocardiograms, and transthoracic echocardiography were performed. Echocardiogram images were analyzed in post-processing using EchoPac software for LA strain quantification, including LA-reservoir, LA-conduit, and LA-contraction strain. Results: The CA group exhibited significantly impaired LA function compared to HCMs and control groups, with LA-reservoir median values of −9%, LA-conduit −6.7%, and LA-contraction −3%; this impairment was consistent even in the CA subgroup with preserved ejection fraction. LA strain parameters correlated with LV mass index, LA volume index, E/e’, and LV-global longitudinal strain and were found to be associated with atrial fibrillation and exertional dyspnea. Conclusions: LA function assessed by STE is significantly impaired in CA patients compared to HCMs patients and healthy controls. These findings highlight the potential supportive role of STE in the early detection and management of the disease.
format Online
Article
Text
id pubmed-10299603
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102996032023-06-28 Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy Monte, Ines Paola Faro, Denise Cristiana Trimarchi, Giancarlo de Gaetano, Fabrizio Campisi, Mariapaola Losi, Valentina Teresi, Lucio Di Bella, Gianluca Tamburino, Corrado de Gregorio, Cesare J Cardiovasc Dev Dis Article Background: Left atrial (LA) function is crucial for assessing left ventricular filling in various cardiovascular conditions. Cardiac Amyloidosis (CA) is characterized by atrial myopathy and LA function impairment, with diastolic dysfunction up to restrictive filling pattern, leading to progressive heart failure and arrhythmias. This study evaluates LA function and deformation using speckle tracking echocardiography (STE) in patients with CA compared to a cohort of patients with sarcomeric Hypertrophic Cardiomyopathy (HCM) and a control group. Methods: We conducted a retrospective, observational study (from January 2019 to December 2022) including a total of 100 patients: 33 with ATTR-CA, 34 with HCMs, and 33 controls. Clinical evaluation, electrocardiograms, and transthoracic echocardiography were performed. Echocardiogram images were analyzed in post-processing using EchoPac software for LA strain quantification, including LA-reservoir, LA-conduit, and LA-contraction strain. Results: The CA group exhibited significantly impaired LA function compared to HCMs and control groups, with LA-reservoir median values of −9%, LA-conduit −6.7%, and LA-contraction −3%; this impairment was consistent even in the CA subgroup with preserved ejection fraction. LA strain parameters correlated with LV mass index, LA volume index, E/e’, and LV-global longitudinal strain and were found to be associated with atrial fibrillation and exertional dyspnea. Conclusions: LA function assessed by STE is significantly impaired in CA patients compared to HCMs patients and healthy controls. These findings highlight the potential supportive role of STE in the early detection and management of the disease. MDPI 2023-06-15 /pmc/articles/PMC10299603/ /pubmed/37367426 http://dx.doi.org/10.3390/jcdd10060261 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monte, Ines Paola
Faro, Denise Cristiana
Trimarchi, Giancarlo
de Gaetano, Fabrizio
Campisi, Mariapaola
Losi, Valentina
Teresi, Lucio
Di Bella, Gianluca
Tamburino, Corrado
de Gregorio, Cesare
Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
title Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
title_full Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
title_fullStr Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
title_full_unstemmed Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
title_short Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
title_sort left atrial strain imaging by speckle tracking echocardiography: the supportive diagnostic value in cardiac amyloidosis and hypertrophic cardiomyopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299603/
https://www.ncbi.nlm.nih.gov/pubmed/37367426
http://dx.doi.org/10.3390/jcdd10060261
work_keys_str_mv AT monteinespaola leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT farodenisecristiana leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT trimarchigiancarlo leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT degaetanofabrizio leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT campisimariapaola leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT losivalentina leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT teresilucio leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT dibellagianluca leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT tamburinocorrado leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy
AT degregoriocesare leftatrialstrainimagingbyspeckletrackingechocardiographythesupportivediagnosticvalueincardiacamyloidosisandhypertrophiccardiomyopathy