Cargando…

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed...

Descripción completa

Detalles Bibliográficos
Autores principales: Farkas, Noémi-Izabella, Marincaș, Laura, Barbu-Tudoran, Lucian, Barabás, Réka, Turdean, Graziella Liana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299625/
https://www.ncbi.nlm.nih.gov/pubmed/37367295
http://dx.doi.org/10.3390/jfb14060331
_version_ 1785064410487717888
author Farkas, Noémi-Izabella
Marincaș, Laura
Barbu-Tudoran, Lucian
Barabás, Réka
Turdean, Graziella Liana
author_facet Farkas, Noémi-Izabella
Marincaș, Laura
Barbu-Tudoran, Lucian
Barabás, Réka
Turdean, Graziella Liana
author_sort Farkas, Noémi-Izabella
collection PubMed
description Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model.
format Online
Article
Text
id pubmed-10299625
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102996252023-06-28 Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers Farkas, Noémi-Izabella Marincaș, Laura Barbu-Tudoran, Lucian Barabás, Réka Turdean, Graziella Liana J Funct Biomater Article Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model. MDPI 2023-06-20 /pmc/articles/PMC10299625/ /pubmed/37367295 http://dx.doi.org/10.3390/jfb14060331 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Farkas, Noémi-Izabella
Marincaș, Laura
Barbu-Tudoran, Lucian
Barabás, Réka
Turdean, Graziella Liana
Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
title Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
title_full Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
title_fullStr Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
title_full_unstemmed Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
title_short Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
title_sort investigation of the real-time release of doxycycline from pla-based nanofibers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299625/
https://www.ncbi.nlm.nih.gov/pubmed/37367295
http://dx.doi.org/10.3390/jfb14060331
work_keys_str_mv AT farkasnoemiizabella investigationoftherealtimereleaseofdoxycyclinefromplabasednanofibers
AT marincaslaura investigationoftherealtimereleaseofdoxycyclinefromplabasednanofibers
AT barbutudoranlucian investigationoftherealtimereleaseofdoxycyclinefromplabasednanofibers
AT barabasreka investigationoftherealtimereleaseofdoxycyclinefromplabasednanofibers
AT turdeangraziellaliana investigationoftherealtimereleaseofdoxycyclinefromplabasednanofibers