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Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299625/ https://www.ncbi.nlm.nih.gov/pubmed/37367295 http://dx.doi.org/10.3390/jfb14060331 |
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author | Farkas, Noémi-Izabella Marincaș, Laura Barbu-Tudoran, Lucian Barabás, Réka Turdean, Graziella Liana |
author_facet | Farkas, Noémi-Izabella Marincaș, Laura Barbu-Tudoran, Lucian Barabás, Réka Turdean, Graziella Liana |
author_sort | Farkas, Noémi-Izabella |
collection | PubMed |
description | Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model. |
format | Online Article Text |
id | pubmed-10299625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102996252023-06-28 Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers Farkas, Noémi-Izabella Marincaș, Laura Barbu-Tudoran, Lucian Barabás, Réka Turdean, Graziella Liana J Funct Biomater Article Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model. MDPI 2023-06-20 /pmc/articles/PMC10299625/ /pubmed/37367295 http://dx.doi.org/10.3390/jfb14060331 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Farkas, Noémi-Izabella Marincaș, Laura Barbu-Tudoran, Lucian Barabás, Réka Turdean, Graziella Liana Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers |
title | Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers |
title_full | Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers |
title_fullStr | Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers |
title_full_unstemmed | Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers |
title_short | Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers |
title_sort | investigation of the real-time release of doxycycline from pla-based nanofibers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299625/ https://www.ncbi.nlm.nih.gov/pubmed/37367295 http://dx.doi.org/10.3390/jfb14060331 |
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