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Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review

The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with s...

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Autores principales: Dróżdż, Wiktor, Wiciński, Michał, Szota, Anna Maria, Szambelan, Monika, Radajewska, Izabela, Popławski, Igor, Wojciechowski, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299654/
https://www.ncbi.nlm.nih.gov/pubmed/37373704
http://dx.doi.org/10.3390/jcm12124012
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author Dróżdż, Wiktor
Wiciński, Michał
Szota, Anna Maria
Szambelan, Monika
Radajewska, Izabela
Popławski, Igor
Wojciechowski, Paweł
author_facet Dróżdż, Wiktor
Wiciński, Michał
Szota, Anna Maria
Szambelan, Monika
Radajewska, Izabela
Popławski, Igor
Wojciechowski, Paweł
author_sort Dróżdż, Wiktor
collection PubMed
description The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with schizophrenia. A systematic search of the PubMed database up to February 2022 was conducted. Inclusion criteria: randomized controlled trials using augmentation therapy in chronic schizophrenia in adults, written in English, and only studies with psychometric assessments of schizophrenia were incorporated. Exclusion criteria: non-clinical, first episode of schizophrenia, patients on medication other than antipsychotics augmented, and not adjunctive therapy. Overall, 37 studies of 1931 patients with schizophrenia who received a combination of antipsychotic medication with other drugs were selected. A statistically significant reduction of negative and positive symptoms of schizophrenia, measured with the PANSS scale, when using a combination of antipsychotic treatment along with aspirin, simvastatin, N-acetylcysteine, or pioglitazone was found. A combination of antipsychotic medication with aspirin, simvastatin, N-acetylcysteine, or pioglitazone seems to be effective in the reduction of symptoms of schizophrenia in adults, but long-term studies are required to confirm this effect.
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spelling pubmed-102996542023-06-28 Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review Dróżdż, Wiktor Wiciński, Michał Szota, Anna Maria Szambelan, Monika Radajewska, Izabela Popławski, Igor Wojciechowski, Paweł J Clin Med Systematic Review The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with schizophrenia. A systematic search of the PubMed database up to February 2022 was conducted. Inclusion criteria: randomized controlled trials using augmentation therapy in chronic schizophrenia in adults, written in English, and only studies with psychometric assessments of schizophrenia were incorporated. Exclusion criteria: non-clinical, first episode of schizophrenia, patients on medication other than antipsychotics augmented, and not adjunctive therapy. Overall, 37 studies of 1931 patients with schizophrenia who received a combination of antipsychotic medication with other drugs were selected. A statistically significant reduction of negative and positive symptoms of schizophrenia, measured with the PANSS scale, when using a combination of antipsychotic treatment along with aspirin, simvastatin, N-acetylcysteine, or pioglitazone was found. A combination of antipsychotic medication with aspirin, simvastatin, N-acetylcysteine, or pioglitazone seems to be effective in the reduction of symptoms of schizophrenia in adults, but long-term studies are required to confirm this effect. MDPI 2023-06-12 /pmc/articles/PMC10299654/ /pubmed/37373704 http://dx.doi.org/10.3390/jcm12124012 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Dróżdż, Wiktor
Wiciński, Michał
Szota, Anna Maria
Szambelan, Monika
Radajewska, Izabela
Popławski, Igor
Wojciechowski, Paweł
Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review
title Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review
title_full Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review
title_fullStr Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review
title_full_unstemmed Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review
title_short Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia—A Systematic Review
title_sort augmentation therapies as treatments for coexisting somatic problems in schizophrenia—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299654/
https://www.ncbi.nlm.nih.gov/pubmed/37373704
http://dx.doi.org/10.3390/jcm12124012
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