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Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors

INTRODUCTION: Paragangliomas (PGL), a type of neuroendocrine tumor, pose a significant diagnostic challenge due to their potential for unpredictable locations and asymptomatic presentation. Misdiagnosis of peripancreatic PGLs, particularly as pancreatic neuroendocrine tumors (PANNETs), is a pressing...

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Autores principales: Enguita, Jose María, Díaz, Ignacio, García, Diego, Cubiella, Tamara, Chiara, María-Dolores, Valdés, Nuria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299733/
https://www.ncbi.nlm.nih.gov/pubmed/37383401
http://dx.doi.org/10.3389/fendo.2023.1162725
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author Enguita, Jose María
Díaz, Ignacio
García, Diego
Cubiella, Tamara
Chiara, María-Dolores
Valdés, Nuria
author_facet Enguita, Jose María
Díaz, Ignacio
García, Diego
Cubiella, Tamara
Chiara, María-Dolores
Valdés, Nuria
author_sort Enguita, Jose María
collection PubMed
description INTRODUCTION: Paragangliomas (PGL), a type of neuroendocrine tumor, pose a significant diagnostic challenge due to their potential for unpredictable locations and asymptomatic presentation. Misdiagnosis of peripancreatic PGLs, particularly as pancreatic neuroendocrine tumors (PANNETs), is a pressing issue as it can negatively impact both pre- and post-treatment decision-making. The aim of our study was to identify microRNA markers for the reliable differential diagnosis of peripancreatic PGLs and PANNETs, addressing a crucial unmet need in the field and advancing the standard of care for these patients. METHODS: Morphing projections tool was used to analyze miRNA data from PGL and PANNET tumors present in the TCGA database. The findings were validated using two additional databases: GSE29742 and GSE73367. RESULTS: Our research uncovered substantial differences in the miRNA expression profiles of PGL and PANNET, leading to the identification of 6 key miRNAs (miR-10b-3p, miR-10b-5p, and the miRNA families miR-200c/141 and miR-194/192) that can effectively differentiate between the two types of tumors. DISCUSSION: These miRNA levels hold potential as biomarkers for improved diagnosis, offering a solution to the diagnostic challenge posed by these tumors and potentially improving the standard of care for patients.
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spelling pubmed-102997332023-06-28 Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors Enguita, Jose María Díaz, Ignacio García, Diego Cubiella, Tamara Chiara, María-Dolores Valdés, Nuria Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Paragangliomas (PGL), a type of neuroendocrine tumor, pose a significant diagnostic challenge due to their potential for unpredictable locations and asymptomatic presentation. Misdiagnosis of peripancreatic PGLs, particularly as pancreatic neuroendocrine tumors (PANNETs), is a pressing issue as it can negatively impact both pre- and post-treatment decision-making. The aim of our study was to identify microRNA markers for the reliable differential diagnosis of peripancreatic PGLs and PANNETs, addressing a crucial unmet need in the field and advancing the standard of care for these patients. METHODS: Morphing projections tool was used to analyze miRNA data from PGL and PANNET tumors present in the TCGA database. The findings were validated using two additional databases: GSE29742 and GSE73367. RESULTS: Our research uncovered substantial differences in the miRNA expression profiles of PGL and PANNET, leading to the identification of 6 key miRNAs (miR-10b-3p, miR-10b-5p, and the miRNA families miR-200c/141 and miR-194/192) that can effectively differentiate between the two types of tumors. DISCUSSION: These miRNA levels hold potential as biomarkers for improved diagnosis, offering a solution to the diagnostic challenge posed by these tumors and potentially improving the standard of care for patients. Frontiers Media S.A. 2023-06-13 /pmc/articles/PMC10299733/ /pubmed/37383401 http://dx.doi.org/10.3389/fendo.2023.1162725 Text en Copyright © 2023 Enguita, Díaz, García, Cubiella, Chiara and Valdés https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Enguita, Jose María
Díaz, Ignacio
García, Diego
Cubiella, Tamara
Chiara, María-Dolores
Valdés, Nuria
Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
title Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
title_full Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
title_fullStr Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
title_full_unstemmed Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
title_short Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
title_sort visual analytics identifies key mirnas for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299733/
https://www.ncbi.nlm.nih.gov/pubmed/37383401
http://dx.doi.org/10.3389/fendo.2023.1162725
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