Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1

Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knockout zebrafish identified an endothelial directional...

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Detalles Bibliográficos
Autores principales: Hipke, Katrin, Pitter, Bettina, Hruscha, Alexander, van Bebber, Frauke, Modic, Miha, Bansal, Vikas, Lewandowski, Sebastian A., Orozco, Denise, Edbauer, Dieter, Bonn, Stefan, Haass, Christian, Pohl, Ulrich, Montanez, Eloi, Schmid, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299809/
https://www.ncbi.nlm.nih.gov/pubmed/37384248
http://dx.doi.org/10.3389/fcell.2023.1169962

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