Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPα(R35A)) that greatly accelerates BMT helped to illuminate the mechanism. Thus, incoming C/EBPα binds...

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Detalles Bibliográficos
Autores principales: Torcal Garcia, Guillem, Kowenz-Leutz, Elisabeth, Tian, Tian V, Klonizakis, Antonis, Lerner, Jonathan, De Andres-Aguayo, Luisa, Sapozhnikova, Valeriia, Berenguer, Clara, Carmona, Marcos Plana, Casadesus, Maria Vila, Bulteau, Romain, Francesconi, Mirko, Peiro, Sandra, Mertins, Philipp, Zaret, Kenneth, Leutz, Achim, Graf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299824/
https://www.ncbi.nlm.nih.gov/pubmed/37365888
http://dx.doi.org/10.7554/eLife.83951

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