Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir

Amorphous salt solid dispersion (ASSD) of Dolutegravir amorphous salt (DSSD) was generated using quench cooling and compared to its Dolutegravir free acid solid dispersion (DFSD) to improve the solubility and bioavailability. Soluplus (SLP) was used as a polymeric carrier in both solid dispersions....

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Detalles Bibliográficos
Autores principales: Yarlagadda, Dani Lakshman, Nayak, Akshatha M., Brahmam, Bheemisetty, Bhat, Krishnamurthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299877/
https://www.ncbi.nlm.nih.gov/pubmed/37383518
http://dx.doi.org/10.1155/2023/7198674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299877/
https://www.ncbi.nlm.nih.gov/pubmed/37383518
http://dx.doi.org/10.1155/2023/7198674

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