Structural basis of efficacy-driven ligand selectivity at GPCRs

A drug’s selectivity for target receptors is essential to its therapeutic utility, but achieving selectivity between similar receptors is challenging. The serendipitous discovery of ligands that stimulate target receptors more strongly than closely related receptors, despite binding with similar aff...

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Detalles Bibliográficos
Autores principales: Powers, Alexander S., Pham, Vi, Burger, Wessel A. C., Thompson, Geoff, Laloudakis, Yianni, Barnes, Nicholas W., Sexton, Patrick M., Paul, Steven M., Christopoulos, Arthur, Thal, David M., Felder, Christian C., Valant, Celine, Dror, Ron O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299909/
https://www.ncbi.nlm.nih.gov/pubmed/36782010
http://dx.doi.org/10.1038/s41589-022-01247-5

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