Cargando…

Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements

Despite being enclosed between the Mediterranean Sea and the Sahara Desert, North Africa has been the scenario of multiple human migrations that have shaped the genetic structure of its present-day populations. Despite its richness, North Africa remains underrepresented in genomic studies. To overco...

Descripción completa

Detalles Bibliográficos
Autores principales: Aizpurua-Iraola, Julen, Abdeli, Amine, Benhassine, Traki, Calafell, Francesc, Comas, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300034/
https://www.ncbi.nlm.nih.gov/pubmed/37369751
http://dx.doi.org/10.1038/s41598-023-37549-4
_version_ 1785064498477924352
author Aizpurua-Iraola, Julen
Abdeli, Amine
Benhassine, Traki
Calafell, Francesc
Comas, David
author_facet Aizpurua-Iraola, Julen
Abdeli, Amine
Benhassine, Traki
Calafell, Francesc
Comas, David
author_sort Aizpurua-Iraola, Julen
collection PubMed
description Despite being enclosed between the Mediterranean Sea and the Sahara Desert, North Africa has been the scenario of multiple human migrations that have shaped the genetic structure of its present-day populations. Despite its richness, North Africa remains underrepresented in genomic studies. To overcome this, we have sequenced and analyzed 264 mitogenomes from the Algerian Chaoui-speaking Imazighen (a.k.a. Berbers) living in the Aurès region. The maternal genetic composition of the Aurès is similar to Arab populations in the region, dominated by West Eurasian lineages with a moderate presence of M1/U6 North African and L sub-Saharan lineages. When focusing on the time and geographic origin of the North African specific clades within the non-autochthonous haplogroups, different geographical neighboring regions contributed to the North African maternal gene pool during time periods that could be attributed to previously suggested admixture events in the region, since Paleolithic times to recent historical movements such as the Arabization. We have also observed the role of North Africa as a source of geneflow mainly in Southern European regions since Neolithic times. Finally, the present work constitutes an effort to increase the representation of North African populations in genetic databases, which is key to understand their history.
format Online
Article
Text
id pubmed-10300034
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-103000342023-06-29 Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements Aizpurua-Iraola, Julen Abdeli, Amine Benhassine, Traki Calafell, Francesc Comas, David Sci Rep Article Despite being enclosed between the Mediterranean Sea and the Sahara Desert, North Africa has been the scenario of multiple human migrations that have shaped the genetic structure of its present-day populations. Despite its richness, North Africa remains underrepresented in genomic studies. To overcome this, we have sequenced and analyzed 264 mitogenomes from the Algerian Chaoui-speaking Imazighen (a.k.a. Berbers) living in the Aurès region. The maternal genetic composition of the Aurès is similar to Arab populations in the region, dominated by West Eurasian lineages with a moderate presence of M1/U6 North African and L sub-Saharan lineages. When focusing on the time and geographic origin of the North African specific clades within the non-autochthonous haplogroups, different geographical neighboring regions contributed to the North African maternal gene pool during time periods that could be attributed to previously suggested admixture events in the region, since Paleolithic times to recent historical movements such as the Arabization. We have also observed the role of North Africa as a source of geneflow mainly in Southern European regions since Neolithic times. Finally, the present work constitutes an effort to increase the representation of North African populations in genetic databases, which is key to understand their history. Nature Publishing Group UK 2023-06-27 /pmc/articles/PMC10300034/ /pubmed/37369751 http://dx.doi.org/10.1038/s41598-023-37549-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Aizpurua-Iraola, Julen
Abdeli, Amine
Benhassine, Traki
Calafell, Francesc
Comas, David
Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
title Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
title_full Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
title_fullStr Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
title_full_unstemmed Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
title_short Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
title_sort whole mitogenomes reveal that nw africa has acted both as a source and a destination for multiple human movements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300034/
https://www.ncbi.nlm.nih.gov/pubmed/37369751
http://dx.doi.org/10.1038/s41598-023-37549-4
work_keys_str_mv AT aizpuruairaolajulen wholemitogenomesrevealthatnwafricahasactedbothasasourceandadestinationformultiplehumanmovements
AT abdeliamine wholemitogenomesrevealthatnwafricahasactedbothasasourceandadestinationformultiplehumanmovements
AT benhassinetraki wholemitogenomesrevealthatnwafricahasactedbothasasourceandadestinationformultiplehumanmovements
AT calafellfrancesc wholemitogenomesrevealthatnwafricahasactedbothasasourceandadestinationformultiplehumanmovements
AT comasdavid wholemitogenomesrevealthatnwafricahasactedbothasasourceandadestinationformultiplehumanmovements