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Deep neural network analysis models for complex random telegraph signals
Time-fluctuating signals are ubiquitous and diverse in many physical, chemical, and biological systems, among which random telegraph signals (RTSs) refer to a series of instantaneous switching events between two discrete levels from single-particle movements. A reliable RTS analysis is a crucial pre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300117/ https://www.ncbi.nlm.nih.gov/pubmed/37369708 http://dx.doi.org/10.1038/s41598-023-37142-9 |
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author | Robitaille, Marcel Yang, HeeBong Wang, Lu Deng, Bowen Kim, Na Young |
author_facet | Robitaille, Marcel Yang, HeeBong Wang, Lu Deng, Bowen Kim, Na Young |
author_sort | Robitaille, Marcel |
collection | PubMed |
description | Time-fluctuating signals are ubiquitous and diverse in many physical, chemical, and biological systems, among which random telegraph signals (RTSs) refer to a series of instantaneous switching events between two discrete levels from single-particle movements. A reliable RTS analysis is a crucial prerequisite to identify underlying mechanisms related to device performance and sensitivity. When numerous levels are involved, complex patterns of multilevel RTSs occur and make their quantitative analysis exponentially difficult, hereby systematic approaches are often elusive. In this work, we present a three-step analysis protocol via progressive knowledge-transfer, where the outputs of the early step are passed onto a subsequent step. Especially, to quantify complex RTSs, we resort to three deep neural network architectures whose trained models can process raw temporal data directly. We furthermore demonstrate the model accuracy extensively with a large dataset of different RTS types in terms of additional background noise types and amplitude size. Our protocol offers structured schemes to extract the parameter values of complex RTSs as imperative information with which researchers can draw meaningful and relevant interpretations and inferences of given devices and systems. |
format | Online Article Text |
id | pubmed-10300117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103001172023-06-29 Deep neural network analysis models for complex random telegraph signals Robitaille, Marcel Yang, HeeBong Wang, Lu Deng, Bowen Kim, Na Young Sci Rep Article Time-fluctuating signals are ubiquitous and diverse in many physical, chemical, and biological systems, among which random telegraph signals (RTSs) refer to a series of instantaneous switching events between two discrete levels from single-particle movements. A reliable RTS analysis is a crucial prerequisite to identify underlying mechanisms related to device performance and sensitivity. When numerous levels are involved, complex patterns of multilevel RTSs occur and make their quantitative analysis exponentially difficult, hereby systematic approaches are often elusive. In this work, we present a three-step analysis protocol via progressive knowledge-transfer, where the outputs of the early step are passed onto a subsequent step. Especially, to quantify complex RTSs, we resort to three deep neural network architectures whose trained models can process raw temporal data directly. We furthermore demonstrate the model accuracy extensively with a large dataset of different RTS types in terms of additional background noise types and amplitude size. Our protocol offers structured schemes to extract the parameter values of complex RTSs as imperative information with which researchers can draw meaningful and relevant interpretations and inferences of given devices and systems. Nature Publishing Group UK 2023-06-27 /pmc/articles/PMC10300117/ /pubmed/37369708 http://dx.doi.org/10.1038/s41598-023-37142-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Robitaille, Marcel Yang, HeeBong Wang, Lu Deng, Bowen Kim, Na Young Deep neural network analysis models for complex random telegraph signals |
title | Deep neural network analysis models for complex random telegraph signals |
title_full | Deep neural network analysis models for complex random telegraph signals |
title_fullStr | Deep neural network analysis models for complex random telegraph signals |
title_full_unstemmed | Deep neural network analysis models for complex random telegraph signals |
title_short | Deep neural network analysis models for complex random telegraph signals |
title_sort | deep neural network analysis models for complex random telegraph signals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300117/ https://www.ncbi.nlm.nih.gov/pubmed/37369708 http://dx.doi.org/10.1038/s41598-023-37142-9 |
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