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Rosai Dorfman Disease in Mandible: A Rare Case Report

Rosai Dorfman disease is generally defined as a massive bilateral painless cervical lymphadenopathy accompanied with both fever and leukocytosis with neutrophilia. Additionally, it may possibly be associated with polyclonal hypergammaglobulinemia, reversal of CD4/CD8 ratio, the elevated erythrocyte...

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Autores principales: Mirmohammad Sadeghi, Hassan, Azadi, Roozbeh, Dehghanpour Barouj, Mehrdad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300144/
https://www.ncbi.nlm.nih.gov/pubmed/37388202
http://dx.doi.org/10.30476/dentjods.2022.95184.1844
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author Mirmohammad Sadeghi, Hassan
Azadi, Roozbeh
Dehghanpour Barouj, Mehrdad
author_facet Mirmohammad Sadeghi, Hassan
Azadi, Roozbeh
Dehghanpour Barouj, Mehrdad
author_sort Mirmohammad Sadeghi, Hassan
collection PubMed
description Rosai Dorfman disease is generally defined as a massive bilateral painless cervical lymphadenopathy accompanied with both fever and leukocytosis with neutrophilia. Additionally, it may possibly be associated with polyclonal hypergammaglobulinemia, reversal of CD4/CD8 ratio, the elevated erythrocyte sedimentation rate (ESR), microcytic anemia, and thrombocytosis. Rosai-Dorfman disease is known as a benign self-limiting disease, so no treatment is required in many cases, although it causes death in some cases by involving vital organs like kidney. The treatment is required when there is a life-threatening situation such as airway obstruction or involvement of vital organs such as kidney, liver, and lower respiratory tract. The required treatment choices include steroid therapy, chemotherapy, radiotherapy, and surgery. Surgical treatment is performed for bulk removal to resolve the obstruction caused by the mass as well as taking biopsy for the definite histopathologic diagnosis of disease. A 26-year-old man was referred to oral and maxillofacial surgery (OMFS) clinic of Taleghani hospital with chief complaints of pain and swelling of left submandibular space. According to the patient himself, the swelling had been started three months earlier. After rejecting dental source of the lesion, we decided to remove the mass by excisional biopsy concerning the patient’s discomfort. Histopathology report verified Rosai Dorfman disease as definite diagnosis of the mass.
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spelling pubmed-103001442023-06-29 Rosai Dorfman Disease in Mandible: A Rare Case Report Mirmohammad Sadeghi, Hassan Azadi, Roozbeh Dehghanpour Barouj, Mehrdad J Dent (Shiraz) Case Report Rosai Dorfman disease is generally defined as a massive bilateral painless cervical lymphadenopathy accompanied with both fever and leukocytosis with neutrophilia. Additionally, it may possibly be associated with polyclonal hypergammaglobulinemia, reversal of CD4/CD8 ratio, the elevated erythrocyte sedimentation rate (ESR), microcytic anemia, and thrombocytosis. Rosai-Dorfman disease is known as a benign self-limiting disease, so no treatment is required in many cases, although it causes death in some cases by involving vital organs like kidney. The treatment is required when there is a life-threatening situation such as airway obstruction or involvement of vital organs such as kidney, liver, and lower respiratory tract. The required treatment choices include steroid therapy, chemotherapy, radiotherapy, and surgery. Surgical treatment is performed for bulk removal to resolve the obstruction caused by the mass as well as taking biopsy for the definite histopathologic diagnosis of disease. A 26-year-old man was referred to oral and maxillofacial surgery (OMFS) clinic of Taleghani hospital with chief complaints of pain and swelling of left submandibular space. According to the patient himself, the swelling had been started three months earlier. After rejecting dental source of the lesion, we decided to remove the mass by excisional biopsy concerning the patient’s discomfort. Histopathology report verified Rosai Dorfman disease as definite diagnosis of the mass. Shiraz University of Medical Sciences 2023-06 /pmc/articles/PMC10300144/ /pubmed/37388202 http://dx.doi.org/10.30476/dentjods.2022.95184.1844 Text en Copyright: © Journal of Dentistry https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits reusers to copy and redistribute the material in any medium or format if the original work is properly cited, and attribution is given to the creator. The license also permits for commercial use.
spellingShingle Case Report
Mirmohammad Sadeghi, Hassan
Azadi, Roozbeh
Dehghanpour Barouj, Mehrdad
Rosai Dorfman Disease in Mandible: A Rare Case Report
title Rosai Dorfman Disease in Mandible: A Rare Case Report
title_full Rosai Dorfman Disease in Mandible: A Rare Case Report
title_fullStr Rosai Dorfman Disease in Mandible: A Rare Case Report
title_full_unstemmed Rosai Dorfman Disease in Mandible: A Rare Case Report
title_short Rosai Dorfman Disease in Mandible: A Rare Case Report
title_sort rosai dorfman disease in mandible: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300144/
https://www.ncbi.nlm.nih.gov/pubmed/37388202
http://dx.doi.org/10.30476/dentjods.2022.95184.1844
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