Acid-sensing ion channel 1a exacerbates renal ischemia–reperfusion injury through the NF-κB/NLRP3 inflammasome pathway

ABSTRACT: Ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury (AKI), and there is no effective therapy. Microenvironmental acidification is generally observed in ischemic tissues. Acid-sensing ion channel 1a (ASIC1a) can be activated by a decrease in extracellular pH which med...

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Detalles Bibliográficos
Autores principales: Yang, Yan, Jin, Shi, Zhang, Jian, Chen, Weize, Lu, Yufei, Chen, Jun, Yan, Zhixin, Shen, Bo, Ning, Yichun, Shi, Yiqin, Chen, Jing, Wang, Jialin, Xu, Sujuan, Jia, Ping, Teng, Jie, Fang, Yi, Song, Nana, Ding, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300185/
https://www.ncbi.nlm.nih.gov/pubmed/37246982
http://dx.doi.org/10.1007/s00109-023-02330-7

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