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Covalent adduction of serotonin-derived quinones to the SARS-CoV-2 main protease expressed in a cultured cell

The SARS-CoV-2 main protease is an essential molecule for viral replication and is often targeted by medications to treat the infection. In this study, we investigated the possible inhibitory action of endogenous quinones on the enzyme. Recombinant SARS-CoV-2 main protease was exposed to tryptamine-...

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Detalles Bibliográficos
Autores principales:	Kato, Yoji, Sakanishi, Asahi, Matsuda, Kaoru, Hattori, Mai, Kaneko, Ichiro, Nishikawa, Miyu, Ikushiro, Shinichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300202/ https://www.ncbi.nlm.nih.gov/pubmed/37391098 http://dx.doi.org/10.1016/j.freeradbiomed.2023.06.018

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