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Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight

Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of developmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating f...

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Autores principales: Szaraz, David, Danek, Zdenek, Lipovy, Bretislav, Krivanek, Jan, Buchtova, Marcela, Moldovan Putnova, Barbora, Putnova, Iveta, Stembirek, Jan, Andrasina, Tomas, Divacka, Petra, Izakovicova Holla, Lydie, Borilova Linhartova, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300219/
https://www.ncbi.nlm.nih.gov/pubmed/37389068
http://dx.doi.org/10.1016/j.heliyon.2023.e17130
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author Szaraz, David
Danek, Zdenek
Lipovy, Bretislav
Krivanek, Jan
Buchtova, Marcela
Moldovan Putnova, Barbora
Putnova, Iveta
Stembirek, Jan
Andrasina, Tomas
Divacka, Petra
Izakovicova Holla, Lydie
Borilova Linhartova, Petra
author_facet Szaraz, David
Danek, Zdenek
Lipovy, Bretislav
Krivanek, Jan
Buchtova, Marcela
Moldovan Putnova, Barbora
Putnova, Iveta
Stembirek, Jan
Andrasina, Tomas
Divacka, Petra
Izakovicova Holla, Lydie
Borilova Linhartova, Petra
author_sort Szaraz, David
collection PubMed
description Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of developmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating from the autosomal dominant polycystic kidney disease (ADPKD) has been, however, explored in much greater detail. This narrative review aimed i) to summarize molecular and cellular processes involved in the formation and growth of developmental OCs, especially dentigerous cysts (DCs) and odontogenic keratocysts (OKCs), ii) to find if there are any similarities in their cystogenesis to ADPKD cysts, and, based on that, iii) to suggest potential factors, candidate molecules, and mechanisms that could be involved in the DC formation, thus proposing further research directions. Here we suggest a possible association of developmental OCs with primary cilia disruption and with hypoxia, which have been previously linked with cyst formation in ADPKD patients. This is illustrated on the imagery of tissues from an ADPKD patient (renal cyst) and from developmental OCs, supporting the similarities in cell proliferation, apoptosis, and primary cilia distribution in DC/OKC/ADPKD tissues. Based on all that, we propose a novel hypothesis of OCs formation suggesting a crucial role of mutations associated with the signaling pathways of primary cilia (in particular, Sonic Hedgehog). These can lead to excessive proliferation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as Hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the OCs development. Based on this, we propose future perspectives in the investigation of OC pathogenesis.
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spelling pubmed-103002192023-06-29 Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight Szaraz, David Danek, Zdenek Lipovy, Bretislav Krivanek, Jan Buchtova, Marcela Moldovan Putnova, Barbora Putnova, Iveta Stembirek, Jan Andrasina, Tomas Divacka, Petra Izakovicova Holla, Lydie Borilova Linhartova, Petra Heliyon Review Article Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of developmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating from the autosomal dominant polycystic kidney disease (ADPKD) has been, however, explored in much greater detail. This narrative review aimed i) to summarize molecular and cellular processes involved in the formation and growth of developmental OCs, especially dentigerous cysts (DCs) and odontogenic keratocysts (OKCs), ii) to find if there are any similarities in their cystogenesis to ADPKD cysts, and, based on that, iii) to suggest potential factors, candidate molecules, and mechanisms that could be involved in the DC formation, thus proposing further research directions. Here we suggest a possible association of developmental OCs with primary cilia disruption and with hypoxia, which have been previously linked with cyst formation in ADPKD patients. This is illustrated on the imagery of tissues from an ADPKD patient (renal cyst) and from developmental OCs, supporting the similarities in cell proliferation, apoptosis, and primary cilia distribution in DC/OKC/ADPKD tissues. Based on all that, we propose a novel hypothesis of OCs formation suggesting a crucial role of mutations associated with the signaling pathways of primary cilia (in particular, Sonic Hedgehog). These can lead to excessive proliferation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as Hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the OCs development. Based on this, we propose future perspectives in the investigation of OC pathogenesis. Elsevier 2023-06-09 /pmc/articles/PMC10300219/ /pubmed/37389068 http://dx.doi.org/10.1016/j.heliyon.2023.e17130 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Szaraz, David
Danek, Zdenek
Lipovy, Bretislav
Krivanek, Jan
Buchtova, Marcela
Moldovan Putnova, Barbora
Putnova, Iveta
Stembirek, Jan
Andrasina, Tomas
Divacka, Petra
Izakovicova Holla, Lydie
Borilova Linhartova, Petra
Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
title Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
title_full Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
title_fullStr Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
title_full_unstemmed Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
title_short Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
title_sort primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – a novel insight
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300219/
https://www.ncbi.nlm.nih.gov/pubmed/37389068
http://dx.doi.org/10.1016/j.heliyon.2023.e17130
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