Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation

The TcK2 protein kinase of Trypanosoma cruzi, the causative agent of Chagas disease, is structurally similar to the human kinase PERK, which phosphorylates the initiation factor eIF2α and, in turn, inhibits translation initiation. We have previously shown that absence of TcK2 kinase impairs parasite...

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Detalles Bibliográficos
Autores principales: Marcelino, Tiago de Paula, Fala, Angela Maria, da Silva, Matheus Monteiro, Souza-Melo, Normanda, Malvezzi, Amaranta Muniz, Klippel, Angélica Hollunder, Zoltner, Martin, Padilla-Mejia, Norma, Kosto, Samantha, Field, Mark C., Burle-Caldas, Gabriela de Assis, Teixeira, Santuza Maria Ribeiro, Couñago, Rafael Miguez, Massirer, Katlin Brauer, Schenkman, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300260/
https://www.ncbi.nlm.nih.gov/pubmed/37230387
http://dx.doi.org/10.1016/j.jbc.2023.104857

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