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Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type

In various cross-sectional and longitudinal studies, exercise has been associated with cardiometabolic outcomes, including high-density lipoprotein (HDL) cholesterol. Exercise-induced changes in HDL cholesterol seem to be affected by genetic polymorphisms. In this study, we examined whether variant...

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Autores principales: Chang, Huan-Cheng, Nfor, Oswald Ndi, Ho, Chien-Chang, Chen, Pei-Hsin, Liaw, Yung-Po
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300272/
https://www.ncbi.nlm.nih.gov/pubmed/37388939
http://dx.doi.org/10.3389/fgene.2023.1136483
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author Chang, Huan-Cheng
Nfor, Oswald Ndi
Ho, Chien-Chang
Chen, Pei-Hsin
Liaw, Yung-Po
author_facet Chang, Huan-Cheng
Nfor, Oswald Ndi
Ho, Chien-Chang
Chen, Pei-Hsin
Liaw, Yung-Po
author_sort Chang, Huan-Cheng
collection PubMed
description In various cross-sectional and longitudinal studies, exercise has been associated with cardiometabolic outcomes, including high-density lipoprotein (HDL) cholesterol. Exercise-induced changes in HDL cholesterol seem to be affected by genetic polymorphisms. In this study, we examined whether variant APOE rs7412 is involved in the association between HDL cholesterol and exercise. From adults assessed in Taiwan Biobank (TWB) between 2008 and 2019, we analyzed data from 57,638 normolipidemic subjects. To examine the association between exercise, APOE rs7412, and HDL cholesterol, a multiple linear regression model was used. A higher HDL was associated with both aerobic exercise (regression coefficient [mg/dL] beta- (β), 1.112; 95% confidence interval (CI); 0.903–1.322) and resistance exercise (β, 2.530; 95% CI, 2.093–2.966). In comparison with the APOE rs7412-CC genotype, the β was 2.589 (95% CI, 2.329–2.848) among those with the CT + TT genotype. Compared to adults who had the CC genotype and did not exercise (the CC/no exercise group), the β-coefficient determined for the different genotype and exercise groups was 1.135 (95% CI, 0.911–1.359) for the CC genotype and aerobic exercise group, 2.753 (95% CI, 2.283–3.322) for the CC genotype and resistance exercise group, 2.705 (95% CI, 2.390–3.020) for the CT + TT genotype and no exercise group, 3.682 (95% CI, 3.218–4.146) for the CT + TT genotype and aerobic exercise group, and 3.855 (95% CI, 2.727–4.982) for the CT + TT genotype and resistance exercise group, respectively. This study demonstrates that self-reported aerobic and resistance exercise both raised HDL levels, yet resistance exercise was associated with a greater increase, particularly among Taiwanese subjects carrying the APOE rs7412-CT+TT genotype.
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spelling pubmed-103002722023-06-29 Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type Chang, Huan-Cheng Nfor, Oswald Ndi Ho, Chien-Chang Chen, Pei-Hsin Liaw, Yung-Po Front Genet Genetics In various cross-sectional and longitudinal studies, exercise has been associated with cardiometabolic outcomes, including high-density lipoprotein (HDL) cholesterol. Exercise-induced changes in HDL cholesterol seem to be affected by genetic polymorphisms. In this study, we examined whether variant APOE rs7412 is involved in the association between HDL cholesterol and exercise. From adults assessed in Taiwan Biobank (TWB) between 2008 and 2019, we analyzed data from 57,638 normolipidemic subjects. To examine the association between exercise, APOE rs7412, and HDL cholesterol, a multiple linear regression model was used. A higher HDL was associated with both aerobic exercise (regression coefficient [mg/dL] beta- (β), 1.112; 95% confidence interval (CI); 0.903–1.322) and resistance exercise (β, 2.530; 95% CI, 2.093–2.966). In comparison with the APOE rs7412-CC genotype, the β was 2.589 (95% CI, 2.329–2.848) among those with the CT + TT genotype. Compared to adults who had the CC genotype and did not exercise (the CC/no exercise group), the β-coefficient determined for the different genotype and exercise groups was 1.135 (95% CI, 0.911–1.359) for the CC genotype and aerobic exercise group, 2.753 (95% CI, 2.283–3.322) for the CC genotype and resistance exercise group, 2.705 (95% CI, 2.390–3.020) for the CT + TT genotype and no exercise group, 3.682 (95% CI, 3.218–4.146) for the CT + TT genotype and aerobic exercise group, and 3.855 (95% CI, 2.727–4.982) for the CT + TT genotype and resistance exercise group, respectively. This study demonstrates that self-reported aerobic and resistance exercise both raised HDL levels, yet resistance exercise was associated with a greater increase, particularly among Taiwanese subjects carrying the APOE rs7412-CT+TT genotype. Frontiers Media S.A. 2023-06-14 /pmc/articles/PMC10300272/ /pubmed/37388939 http://dx.doi.org/10.3389/fgene.2023.1136483 Text en Copyright © 2023 Chang, Nfor, Ho, Chen and Liaw. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Chang, Huan-Cheng
Nfor, Oswald Ndi
Ho, Chien-Chang
Chen, Pei-Hsin
Liaw, Yung-Po
Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
title Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
title_full Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
title_fullStr Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
title_full_unstemmed Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
title_short Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
title_sort variations in high density cholesterol levels based on apolipoprotein e variant and exercise type
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300272/
https://www.ncbi.nlm.nih.gov/pubmed/37388939
http://dx.doi.org/10.3389/fgene.2023.1136483
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