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Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
In various cross-sectional and longitudinal studies, exercise has been associated with cardiometabolic outcomes, including high-density lipoprotein (HDL) cholesterol. Exercise-induced changes in HDL cholesterol seem to be affected by genetic polymorphisms. In this study, we examined whether variant...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300272/ https://www.ncbi.nlm.nih.gov/pubmed/37388939 http://dx.doi.org/10.3389/fgene.2023.1136483 |
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author | Chang, Huan-Cheng Nfor, Oswald Ndi Ho, Chien-Chang Chen, Pei-Hsin Liaw, Yung-Po |
author_facet | Chang, Huan-Cheng Nfor, Oswald Ndi Ho, Chien-Chang Chen, Pei-Hsin Liaw, Yung-Po |
author_sort | Chang, Huan-Cheng |
collection | PubMed |
description | In various cross-sectional and longitudinal studies, exercise has been associated with cardiometabolic outcomes, including high-density lipoprotein (HDL) cholesterol. Exercise-induced changes in HDL cholesterol seem to be affected by genetic polymorphisms. In this study, we examined whether variant APOE rs7412 is involved in the association between HDL cholesterol and exercise. From adults assessed in Taiwan Biobank (TWB) between 2008 and 2019, we analyzed data from 57,638 normolipidemic subjects. To examine the association between exercise, APOE rs7412, and HDL cholesterol, a multiple linear regression model was used. A higher HDL was associated with both aerobic exercise (regression coefficient [mg/dL] beta- (β), 1.112; 95% confidence interval (CI); 0.903–1.322) and resistance exercise (β, 2.530; 95% CI, 2.093–2.966). In comparison with the APOE rs7412-CC genotype, the β was 2.589 (95% CI, 2.329–2.848) among those with the CT + TT genotype. Compared to adults who had the CC genotype and did not exercise (the CC/no exercise group), the β-coefficient determined for the different genotype and exercise groups was 1.135 (95% CI, 0.911–1.359) for the CC genotype and aerobic exercise group, 2.753 (95% CI, 2.283–3.322) for the CC genotype and resistance exercise group, 2.705 (95% CI, 2.390–3.020) for the CT + TT genotype and no exercise group, 3.682 (95% CI, 3.218–4.146) for the CT + TT genotype and aerobic exercise group, and 3.855 (95% CI, 2.727–4.982) for the CT + TT genotype and resistance exercise group, respectively. This study demonstrates that self-reported aerobic and resistance exercise both raised HDL levels, yet resistance exercise was associated with a greater increase, particularly among Taiwanese subjects carrying the APOE rs7412-CT+TT genotype. |
format | Online Article Text |
id | pubmed-10300272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103002722023-06-29 Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type Chang, Huan-Cheng Nfor, Oswald Ndi Ho, Chien-Chang Chen, Pei-Hsin Liaw, Yung-Po Front Genet Genetics In various cross-sectional and longitudinal studies, exercise has been associated with cardiometabolic outcomes, including high-density lipoprotein (HDL) cholesterol. Exercise-induced changes in HDL cholesterol seem to be affected by genetic polymorphisms. In this study, we examined whether variant APOE rs7412 is involved in the association between HDL cholesterol and exercise. From adults assessed in Taiwan Biobank (TWB) between 2008 and 2019, we analyzed data from 57,638 normolipidemic subjects. To examine the association between exercise, APOE rs7412, and HDL cholesterol, a multiple linear regression model was used. A higher HDL was associated with both aerobic exercise (regression coefficient [mg/dL] beta- (β), 1.112; 95% confidence interval (CI); 0.903–1.322) and resistance exercise (β, 2.530; 95% CI, 2.093–2.966). In comparison with the APOE rs7412-CC genotype, the β was 2.589 (95% CI, 2.329–2.848) among those with the CT + TT genotype. Compared to adults who had the CC genotype and did not exercise (the CC/no exercise group), the β-coefficient determined for the different genotype and exercise groups was 1.135 (95% CI, 0.911–1.359) for the CC genotype and aerobic exercise group, 2.753 (95% CI, 2.283–3.322) for the CC genotype and resistance exercise group, 2.705 (95% CI, 2.390–3.020) for the CT + TT genotype and no exercise group, 3.682 (95% CI, 3.218–4.146) for the CT + TT genotype and aerobic exercise group, and 3.855 (95% CI, 2.727–4.982) for the CT + TT genotype and resistance exercise group, respectively. This study demonstrates that self-reported aerobic and resistance exercise both raised HDL levels, yet resistance exercise was associated with a greater increase, particularly among Taiwanese subjects carrying the APOE rs7412-CT+TT genotype. Frontiers Media S.A. 2023-06-14 /pmc/articles/PMC10300272/ /pubmed/37388939 http://dx.doi.org/10.3389/fgene.2023.1136483 Text en Copyright © 2023 Chang, Nfor, Ho, Chen and Liaw. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Chang, Huan-Cheng Nfor, Oswald Ndi Ho, Chien-Chang Chen, Pei-Hsin Liaw, Yung-Po Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type |
title | Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type |
title_full | Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type |
title_fullStr | Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type |
title_full_unstemmed | Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type |
title_short | Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type |
title_sort | variations in high density cholesterol levels based on apolipoprotein e variant and exercise type |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300272/ https://www.ncbi.nlm.nih.gov/pubmed/37388939 http://dx.doi.org/10.3389/fgene.2023.1136483 |
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