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How does exercise affect energy metabolism? An in silico approach for cardiac muscle

We explored an in silico model of muscle energy metabolism and demonstrated its theoretical plausibility. Results indicate that energy metabolism triggered by activation can capture the muscle condition, rest, or exercise, and can respond accordingly adjusting the rates of their respiration and ener...

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Autores principales: Yalçınkaya, Bahar Hazal, Genc, Seda, Yılmaz, Bayram, Özilgen, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300317/
https://www.ncbi.nlm.nih.gov/pubmed/37389084
http://dx.doi.org/10.1016/j.heliyon.2023.e17164
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author Yalçınkaya, Bahar Hazal
Genc, Seda
Yılmaz, Bayram
Özilgen, Mustafa
author_facet Yalçınkaya, Bahar Hazal
Genc, Seda
Yılmaz, Bayram
Özilgen, Mustafa
author_sort Yalçınkaya, Bahar Hazal
collection PubMed
description We explored an in silico model of muscle energy metabolism and demonstrated its theoretical plausibility. Results indicate that energy metabolism triggered by activation can capture the muscle condition, rest, or exercise, and can respond accordingly adjusting the rates of their respiration and energy utilization for efficient use of the nutrients. Our study demonstrated during exercise higher respiratory activity causes a substantial increase in exergy release with an increase in exergy destruction, and entropy generation rate. The thermodynamic analysis showed that at the resting state when the exergy destruction rate was 0.66 W/kg and the respiratory metabolism energetic efficiency was 36% and exergetic efficiency was 32%; whereas, when the exergy destroyed was 1.24 W/kg, the energetic efficiency was 58% and exergetic efficiency was 50% during exercise. The efficiency results suggest the ability of the system to regulate itself in response to higher work demand and become more efficient in terms of converting energy coming from nutrients to useable energy when the circulating medium has sufficient energy precursor.
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spelling pubmed-103003172023-06-29 How does exercise affect energy metabolism? An in silico approach for cardiac muscle Yalçınkaya, Bahar Hazal Genc, Seda Yılmaz, Bayram Özilgen, Mustafa Heliyon Research Article We explored an in silico model of muscle energy metabolism and demonstrated its theoretical plausibility. Results indicate that energy metabolism triggered by activation can capture the muscle condition, rest, or exercise, and can respond accordingly adjusting the rates of their respiration and energy utilization for efficient use of the nutrients. Our study demonstrated during exercise higher respiratory activity causes a substantial increase in exergy release with an increase in exergy destruction, and entropy generation rate. The thermodynamic analysis showed that at the resting state when the exergy destruction rate was 0.66 W/kg and the respiratory metabolism energetic efficiency was 36% and exergetic efficiency was 32%; whereas, when the exergy destroyed was 1.24 W/kg, the energetic efficiency was 58% and exergetic efficiency was 50% during exercise. The efficiency results suggest the ability of the system to regulate itself in response to higher work demand and become more efficient in terms of converting energy coming from nutrients to useable energy when the circulating medium has sufficient energy precursor. Elsevier 2023-06-13 /pmc/articles/PMC10300317/ /pubmed/37389084 http://dx.doi.org/10.1016/j.heliyon.2023.e17164 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Yalçınkaya, Bahar Hazal
Genc, Seda
Yılmaz, Bayram
Özilgen, Mustafa
How does exercise affect energy metabolism? An in silico approach for cardiac muscle
title How does exercise affect energy metabolism? An in silico approach for cardiac muscle
title_full How does exercise affect energy metabolism? An in silico approach for cardiac muscle
title_fullStr How does exercise affect energy metabolism? An in silico approach for cardiac muscle
title_full_unstemmed How does exercise affect energy metabolism? An in silico approach for cardiac muscle
title_short How does exercise affect energy metabolism? An in silico approach for cardiac muscle
title_sort how does exercise affect energy metabolism? an in silico approach for cardiac muscle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300317/
https://www.ncbi.nlm.nih.gov/pubmed/37389084
http://dx.doi.org/10.1016/j.heliyon.2023.e17164
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