Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response

We developed recombinant variants of oncolytic vaccinia virus LIVP strain expressing interleukin-15 (IL-15) or its receptor subunit alpha (IL-15Rα) to stimulate IL-15-dependent immune cells. We evaluated their oncolytic activity either alone or in combination with each other in vitro and in vivo usi...

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Detalles Bibliográficos
Autores principales: Shakiba, Yasmin, Vorobyev, Pavel O., Yusubalieva, Gaukhar M., Kochetkov, Dmitry V., Zajtseva, Ksenia V., Valikhov, Marat P., Kalsin, Vladimir A., Zabozlaev, Fedor G., Semkina, Alevtina S., Troitskiy, Alexander V., Baklaushev, Vladimir P., Chumakov, Peter M., Lipatova, Anastasia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300409/
https://www.ncbi.nlm.nih.gov/pubmed/37387795
http://dx.doi.org/10.1016/j.omto.2023.05.002

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