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Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model

BACKGROUND: This study evaluated occupational exposure levels of doxorubicin in healthcare workers performing rotational intraperitoneal pressurized aerosol chemotherapy (PIPAC) procedures. METHODS: All samples were collected during PIPAC procedures applying doxorubicin to an experimental animal mod...

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Autores principales: Jung, Wongeon, Park, Mijin, Park, Soo Jin, Lee, Eun Ji, Kim, Hee Seung, Chung, Sun Ho, Yoon, Chungsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Occupational Safety and Health Research Institute 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300457/
https://www.ncbi.nlm.nih.gov/pubmed/37389318
http://dx.doi.org/10.1016/j.shaw.2023.04.002
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author Jung, Wongeon
Park, Mijin
Park, Soo Jin
Lee, Eun Ji
Kim, Hee Seung
Chung, Sun Ho
Yoon, Chungsik
author_facet Jung, Wongeon
Park, Mijin
Park, Soo Jin
Lee, Eun Ji
Kim, Hee Seung
Chung, Sun Ho
Yoon, Chungsik
author_sort Jung, Wongeon
collection PubMed
description BACKGROUND: This study evaluated occupational exposure levels of doxorubicin in healthcare workers performing rotational intraperitoneal pressurized aerosol chemotherapy (PIPAC) procedures. METHODS: All samples were collected during PIPAC procedures applying doxorubicin to an experimental animal model (pigs). All procedures were applied to seven pigs, each for approximately 44 min. Surface samples (n = 51) were obtained from substances contaminating the PIPAC devices, surrounding objects, and protective equipment. Airborne samples were also collected around the operating table (n = 39). All samples were analyzed using ultra-high performance liquid chromatography-mass spectrometry. RESULTS: Among the surface samples, doxorubicin was detected in only five samples (9.8%) that were directly exposed to antineoplastic drug aerosols in the abdominal cavity originating from PIPAC devices. The telescopes showed concentrations of 0.48–5.44 ng/cm(2) and the trocar showed 0.98 ng/cm(2) in the region where the spraying nozzles were inserted. The syringe line connector showed a maximum concentration of 181.07 ng/cm(2), following a leakage. Contamination was not detected on the surgeons' gloves or shoes. Objects surrounding the operating table, including tables, operating lights, entrance doors, and trocar holders, were found to be uncontaminated. All air samples collected at locations where healthcare workers performed procedures were found to be uncontaminated. CONCLUSIONS: Most air and surface samples were uncontaminated or showed very low doxorubicin concentrations during PIPAC procedures. However, there remains a potential for leakage, in which case dermal exposure may occur. Safety protocols related to leakage accidents, selection of appropriate protective equipment, and the use of disposable devices are necessary to prevent occupational exposure.
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spelling pubmed-103004572023-06-29 Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model Jung, Wongeon Park, Mijin Park, Soo Jin Lee, Eun Ji Kim, Hee Seung Chung, Sun Ho Yoon, Chungsik Saf Health Work Original Article BACKGROUND: This study evaluated occupational exposure levels of doxorubicin in healthcare workers performing rotational intraperitoneal pressurized aerosol chemotherapy (PIPAC) procedures. METHODS: All samples were collected during PIPAC procedures applying doxorubicin to an experimental animal model (pigs). All procedures were applied to seven pigs, each for approximately 44 min. Surface samples (n = 51) were obtained from substances contaminating the PIPAC devices, surrounding objects, and protective equipment. Airborne samples were also collected around the operating table (n = 39). All samples were analyzed using ultra-high performance liquid chromatography-mass spectrometry. RESULTS: Among the surface samples, doxorubicin was detected in only five samples (9.8%) that were directly exposed to antineoplastic drug aerosols in the abdominal cavity originating from PIPAC devices. The telescopes showed concentrations of 0.48–5.44 ng/cm(2) and the trocar showed 0.98 ng/cm(2) in the region where the spraying nozzles were inserted. The syringe line connector showed a maximum concentration of 181.07 ng/cm(2), following a leakage. Contamination was not detected on the surgeons' gloves or shoes. Objects surrounding the operating table, including tables, operating lights, entrance doors, and trocar holders, were found to be uncontaminated. All air samples collected at locations where healthcare workers performed procedures were found to be uncontaminated. CONCLUSIONS: Most air and surface samples were uncontaminated or showed very low doxorubicin concentrations during PIPAC procedures. However, there remains a potential for leakage, in which case dermal exposure may occur. Safety protocols related to leakage accidents, selection of appropriate protective equipment, and the use of disposable devices are necessary to prevent occupational exposure. Occupational Safety and Health Research Institute 2023-06 2023-04-11 /pmc/articles/PMC10300457/ /pubmed/37389318 http://dx.doi.org/10.1016/j.shaw.2023.04.002 Text en © 2023 Occupational Safety and Health Research Institute https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Jung, Wongeon
Park, Mijin
Park, Soo Jin
Lee, Eun Ji
Kim, Hee Seung
Chung, Sun Ho
Yoon, Chungsik
Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
title Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
title_full Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
title_fullStr Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
title_full_unstemmed Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
title_short Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
title_sort occupational exposure during intraperitoneal pressurized aerosol chemotherapy using doxorubicin in a pig model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300457/
https://www.ncbi.nlm.nih.gov/pubmed/37389318
http://dx.doi.org/10.1016/j.shaw.2023.04.002
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