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Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate (up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low temperature, wide pH range, low availability of nutrients), it is widespread in the environment, e.g., water, soil, or f...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300472/ https://www.ncbi.nlm.nih.gov/pubmed/37388250 http://dx.doi.org/10.3389/fmolb.2023.1161486 |
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author | Wiktorczyk-Kapischke, Natalia Skowron, Krzysztof Wałecka-Zacharska, Ewa |
author_facet | Wiktorczyk-Kapischke, Natalia Skowron, Krzysztof Wałecka-Zacharska, Ewa |
author_sort | Wiktorczyk-Kapischke, Natalia |
collection | PubMed |
description | Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate (up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low temperature, wide pH range, low availability of nutrients), it is widespread in the environment, e.g., water, soil, or food. L. monocytogenes possess a number of genes that determine its high virulence potential, i.e., genes involved in the intracellular cycle (e.g., prfA, hly, plcA, plcB, inlA, inlB), response to stress conditions (e.g., sigB, gadA, caspD, clpB, lmo1138), biofilm formation (e.g., agr, luxS), or resistance to disinfectants (e.g., emrELm, bcrABC, mdrL). Some genes are organized into genomic and pathogenicity islands. The islands LIPI-1 and LIPI-3 contain genes related to the infectious life cycle and survival in the food processing environment, while LGI-1 and LGI-2 potentially ensure survival and durability in the production environment. Researchers constantly have been searching for new genes determining the virulence of L. monocytogenes. Understanding the virulence potential of L. monocytogenes is an important element of public health protection, as highly pathogenic strains may be associated with outbreaks and the severity of listeriosis. This review summarizes the selected aspects of L. monocytogenes genomic and pathogenicity islands, and the importance of whole genome sequencing for epidemiological purposes. |
format | Online Article Text |
id | pubmed-10300472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103004722023-06-29 Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects Wiktorczyk-Kapischke, Natalia Skowron, Krzysztof Wałecka-Zacharska, Ewa Front Mol Biosci Molecular Biosciences Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate (up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low temperature, wide pH range, low availability of nutrients), it is widespread in the environment, e.g., water, soil, or food. L. monocytogenes possess a number of genes that determine its high virulence potential, i.e., genes involved in the intracellular cycle (e.g., prfA, hly, plcA, plcB, inlA, inlB), response to stress conditions (e.g., sigB, gadA, caspD, clpB, lmo1138), biofilm formation (e.g., agr, luxS), or resistance to disinfectants (e.g., emrELm, bcrABC, mdrL). Some genes are organized into genomic and pathogenicity islands. The islands LIPI-1 and LIPI-3 contain genes related to the infectious life cycle and survival in the food processing environment, while LGI-1 and LGI-2 potentially ensure survival and durability in the production environment. Researchers constantly have been searching for new genes determining the virulence of L. monocytogenes. Understanding the virulence potential of L. monocytogenes is an important element of public health protection, as highly pathogenic strains may be associated with outbreaks and the severity of listeriosis. This review summarizes the selected aspects of L. monocytogenes genomic and pathogenicity islands, and the importance of whole genome sequencing for epidemiological purposes. Frontiers Media S.A. 2023-06-14 /pmc/articles/PMC10300472/ /pubmed/37388250 http://dx.doi.org/10.3389/fmolb.2023.1161486 Text en Copyright © 2023 Wiktorczyk-Kapischke, Skowron and Wałecka-Zacharska. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Wiktorczyk-Kapischke, Natalia Skowron, Krzysztof Wałecka-Zacharska, Ewa Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects |
title | Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects |
title_full | Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects |
title_fullStr | Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects |
title_full_unstemmed | Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects |
title_short | Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects |
title_sort | genomic and pathogenicity islands of listeria monocytogenes—overview of selected aspects |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300472/ https://www.ncbi.nlm.nih.gov/pubmed/37388250 http://dx.doi.org/10.3389/fmolb.2023.1161486 |
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