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Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects

Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate (up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low temperature, wide pH range, low availability of nutrients), it is widespread in the environment, e.g., water, soil, or f...

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Autores principales: Wiktorczyk-Kapischke, Natalia, Skowron, Krzysztof, Wałecka-Zacharska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300472/
https://www.ncbi.nlm.nih.gov/pubmed/37388250
http://dx.doi.org/10.3389/fmolb.2023.1161486
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author Wiktorczyk-Kapischke, Natalia
Skowron, Krzysztof
Wałecka-Zacharska, Ewa
author_facet Wiktorczyk-Kapischke, Natalia
Skowron, Krzysztof
Wałecka-Zacharska, Ewa
author_sort Wiktorczyk-Kapischke, Natalia
collection PubMed
description Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate (up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low temperature, wide pH range, low availability of nutrients), it is widespread in the environment, e.g., water, soil, or food. L. monocytogenes possess a number of genes that determine its high virulence potential, i.e., genes involved in the intracellular cycle (e.g., prfA, hly, plcA, plcB, inlA, inlB), response to stress conditions (e.g., sigB, gadA, caspD, clpB, lmo1138), biofilm formation (e.g., agr, luxS), or resistance to disinfectants (e.g., emrELm, bcrABC, mdrL). Some genes are organized into genomic and pathogenicity islands. The islands LIPI-1 and LIPI-3 contain genes related to the infectious life cycle and survival in the food processing environment, while LGI-1 and LGI-2 potentially ensure survival and durability in the production environment. Researchers constantly have been searching for new genes determining the virulence of L. monocytogenes. Understanding the virulence potential of L. monocytogenes is an important element of public health protection, as highly pathogenic strains may be associated with outbreaks and the severity of listeriosis. This review summarizes the selected aspects of L. monocytogenes genomic and pathogenicity islands, and the importance of whole genome sequencing for epidemiological purposes.
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spelling pubmed-103004722023-06-29 Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects Wiktorczyk-Kapischke, Natalia Skowron, Krzysztof Wałecka-Zacharska, Ewa Front Mol Biosci Molecular Biosciences Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate (up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low temperature, wide pH range, low availability of nutrients), it is widespread in the environment, e.g., water, soil, or food. L. monocytogenes possess a number of genes that determine its high virulence potential, i.e., genes involved in the intracellular cycle (e.g., prfA, hly, plcA, plcB, inlA, inlB), response to stress conditions (e.g., sigB, gadA, caspD, clpB, lmo1138), biofilm formation (e.g., agr, luxS), or resistance to disinfectants (e.g., emrELm, bcrABC, mdrL). Some genes are organized into genomic and pathogenicity islands. The islands LIPI-1 and LIPI-3 contain genes related to the infectious life cycle and survival in the food processing environment, while LGI-1 and LGI-2 potentially ensure survival and durability in the production environment. Researchers constantly have been searching for new genes determining the virulence of L. monocytogenes. Understanding the virulence potential of L. monocytogenes is an important element of public health protection, as highly pathogenic strains may be associated with outbreaks and the severity of listeriosis. This review summarizes the selected aspects of L. monocytogenes genomic and pathogenicity islands, and the importance of whole genome sequencing for epidemiological purposes. Frontiers Media S.A. 2023-06-14 /pmc/articles/PMC10300472/ /pubmed/37388250 http://dx.doi.org/10.3389/fmolb.2023.1161486 Text en Copyright © 2023 Wiktorczyk-Kapischke, Skowron and Wałecka-Zacharska. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Wiktorczyk-Kapischke, Natalia
Skowron, Krzysztof
Wałecka-Zacharska, Ewa
Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
title Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
title_full Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
title_fullStr Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
title_full_unstemmed Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
title_short Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects
title_sort genomic and pathogenicity islands of listeria monocytogenes—overview of selected aspects
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300472/
https://www.ncbi.nlm.nih.gov/pubmed/37388250
http://dx.doi.org/10.3389/fmolb.2023.1161486
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