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Targeting Peptides: The New Generation of Targeted Drug Delivery Systems

Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tum...

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Detalles Bibliográficos
Autores principales: Todaro, Biagio, Ottalagana, Elisa, Luin, Stefano, Santi, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300729/
https://www.ncbi.nlm.nih.gov/pubmed/37376097
http://dx.doi.org/10.3390/pharmaceutics15061648
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author Todaro, Biagio
Ottalagana, Elisa
Luin, Stefano
Santi, Melissa
author_facet Todaro, Biagio
Ottalagana, Elisa
Luin, Stefano
Santi, Melissa
author_sort Todaro, Biagio
collection PubMed
description Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tumors to central nervous system disorders, also thanks to the ability of some of them to cross the blood–brain barrier. In this review, we will describe the techniques employed for their experimental and in silico design, as well as their possible applications. We will also discuss advancements in their formulation and chemical modifications that make them even more stable and effective. Finally, we will discuss how their use could effectively help to overcome various physiological problems and improve existing treatments.
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spelling pubmed-103007292023-06-29 Targeting Peptides: The New Generation of Targeted Drug Delivery Systems Todaro, Biagio Ottalagana, Elisa Luin, Stefano Santi, Melissa Pharmaceutics Review Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tumors to central nervous system disorders, also thanks to the ability of some of them to cross the blood–brain barrier. In this review, we will describe the techniques employed for their experimental and in silico design, as well as their possible applications. We will also discuss advancements in their formulation and chemical modifications that make them even more stable and effective. Finally, we will discuss how their use could effectively help to overcome various physiological problems and improve existing treatments. MDPI 2023-06-03 /pmc/articles/PMC10300729/ /pubmed/37376097 http://dx.doi.org/10.3390/pharmaceutics15061648 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Todaro, Biagio
Ottalagana, Elisa
Luin, Stefano
Santi, Melissa
Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
title Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
title_full Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
title_fullStr Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
title_full_unstemmed Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
title_short Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
title_sort targeting peptides: the new generation of targeted drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300729/
https://www.ncbi.nlm.nih.gov/pubmed/37376097
http://dx.doi.org/10.3390/pharmaceutics15061648
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