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Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tum...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300729/ https://www.ncbi.nlm.nih.gov/pubmed/37376097 http://dx.doi.org/10.3390/pharmaceutics15061648 |
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author | Todaro, Biagio Ottalagana, Elisa Luin, Stefano Santi, Melissa |
author_facet | Todaro, Biagio Ottalagana, Elisa Luin, Stefano Santi, Melissa |
author_sort | Todaro, Biagio |
collection | PubMed |
description | Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tumors to central nervous system disorders, also thanks to the ability of some of them to cross the blood–brain barrier. In this review, we will describe the techniques employed for their experimental and in silico design, as well as their possible applications. We will also discuss advancements in their formulation and chemical modifications that make them even more stable and effective. Finally, we will discuss how their use could effectively help to overcome various physiological problems and improve existing treatments. |
format | Online Article Text |
id | pubmed-10300729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103007292023-06-29 Targeting Peptides: The New Generation of Targeted Drug Delivery Systems Todaro, Biagio Ottalagana, Elisa Luin, Stefano Santi, Melissa Pharmaceutics Review Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tumors to central nervous system disorders, also thanks to the ability of some of them to cross the blood–brain barrier. In this review, we will describe the techniques employed for their experimental and in silico design, as well as their possible applications. We will also discuss advancements in their formulation and chemical modifications that make them even more stable and effective. Finally, we will discuss how their use could effectively help to overcome various physiological problems and improve existing treatments. MDPI 2023-06-03 /pmc/articles/PMC10300729/ /pubmed/37376097 http://dx.doi.org/10.3390/pharmaceutics15061648 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Todaro, Biagio Ottalagana, Elisa Luin, Stefano Santi, Melissa Targeting Peptides: The New Generation of Targeted Drug Delivery Systems |
title | Targeting Peptides: The New Generation of Targeted Drug Delivery Systems |
title_full | Targeting Peptides: The New Generation of Targeted Drug Delivery Systems |
title_fullStr | Targeting Peptides: The New Generation of Targeted Drug Delivery Systems |
title_full_unstemmed | Targeting Peptides: The New Generation of Targeted Drug Delivery Systems |
title_short | Targeting Peptides: The New Generation of Targeted Drug Delivery Systems |
title_sort | targeting peptides: the new generation of targeted drug delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300729/ https://www.ncbi.nlm.nih.gov/pubmed/37376097 http://dx.doi.org/10.3390/pharmaceutics15061648 |
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