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Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers

Multi-arm star-shaped block copolymers with precisely tuned nano-architectures are promising candidates for drug delivery. Herein, we developed 4- and 6-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) as the core-forming segments and biocompatible poly(ethylene glycol) (...

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Autores principales: Nakagawa, Yasuhiro, Ushidome, Kotaro, Masuda, Keita, Igarashi, Kazunori, Matsumoto, Yu, Yamasoba, Tatsuya, Anraku, Yasutaka, Takai, Madoka, Cabral, Horacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300759/
https://www.ncbi.nlm.nih.gov/pubmed/37376272
http://dx.doi.org/10.3390/polym15122626
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author Nakagawa, Yasuhiro
Ushidome, Kotaro
Masuda, Keita
Igarashi, Kazunori
Matsumoto, Yu
Yamasoba, Tatsuya
Anraku, Yasutaka
Takai, Madoka
Cabral, Horacio
author_facet Nakagawa, Yasuhiro
Ushidome, Kotaro
Masuda, Keita
Igarashi, Kazunori
Matsumoto, Yu
Yamasoba, Tatsuya
Anraku, Yasutaka
Takai, Madoka
Cabral, Horacio
author_sort Nakagawa, Yasuhiro
collection PubMed
description Multi-arm star-shaped block copolymers with precisely tuned nano-architectures are promising candidates for drug delivery. Herein, we developed 4- and 6-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) as the core-forming segments and biocompatible poly(ethylene glycol) (PEG) as the shell-forming blocks. The polymerization degree of each block was controlled by adjusting the feeding ratio of a furfuryl glycidyl ether and ethylene oxide. The size of the series of block copolymers was found to be less than 10 nm in DMF. In water, the polymers showed sizes larger than 20 nm, which can be related to the association of the polymers. The star-shaped block copolymers effectively loaded maleimide-bearing model drugs in their core-forming segment with the Diels–Alder reaction. These drugs were rapidly released upon heating via a retro Diels–Alder step. When the star-shaped block copolymers were injected intravenously in mice, they showed prolonged blood circulation, with more than 80% of the injected dose remaining in the bloodstream at 6 h after intravenous injection. These results indicate the potential of the star-shaped PFG-PEG block copolymers as long-circulating nanocarriers.
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spelling pubmed-103007592023-06-29 Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers Nakagawa, Yasuhiro Ushidome, Kotaro Masuda, Keita Igarashi, Kazunori Matsumoto, Yu Yamasoba, Tatsuya Anraku, Yasutaka Takai, Madoka Cabral, Horacio Polymers (Basel) Article Multi-arm star-shaped block copolymers with precisely tuned nano-architectures are promising candidates for drug delivery. Herein, we developed 4- and 6-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) as the core-forming segments and biocompatible poly(ethylene glycol) (PEG) as the shell-forming blocks. The polymerization degree of each block was controlled by adjusting the feeding ratio of a furfuryl glycidyl ether and ethylene oxide. The size of the series of block copolymers was found to be less than 10 nm in DMF. In water, the polymers showed sizes larger than 20 nm, which can be related to the association of the polymers. The star-shaped block copolymers effectively loaded maleimide-bearing model drugs in their core-forming segment with the Diels–Alder reaction. These drugs were rapidly released upon heating via a retro Diels–Alder step. When the star-shaped block copolymers were injected intravenously in mice, they showed prolonged blood circulation, with more than 80% of the injected dose remaining in the bloodstream at 6 h after intravenous injection. These results indicate the potential of the star-shaped PFG-PEG block copolymers as long-circulating nanocarriers. MDPI 2023-06-09 /pmc/articles/PMC10300759/ /pubmed/37376272 http://dx.doi.org/10.3390/polym15122626 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nakagawa, Yasuhiro
Ushidome, Kotaro
Masuda, Keita
Igarashi, Kazunori
Matsumoto, Yu
Yamasoba, Tatsuya
Anraku, Yasutaka
Takai, Madoka
Cabral, Horacio
Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers
title Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers
title_full Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers
title_fullStr Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers
title_full_unstemmed Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers
title_short Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers
title_sort multi-armed star-shaped block copolymers of poly(ethylene glycol)-poly(furfuryl glycidol) as long circulating nanocarriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300759/
https://www.ncbi.nlm.nih.gov/pubmed/37376272
http://dx.doi.org/10.3390/polym15122626
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