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Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A

Factor V (FV) Leiden and prothrombin G20210A are the most common hereditary thrombophilias. While their role in venous thromboembolism is well known, there are still uncertainties regarding their relationship with arterial thrombotic events, especially coronary ones. Our research, based on an in-dep...

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Autores principales: Badescu, Minerva Codruta, Butnariu, Lăcrămioara Ionela, Costache, Alexandru Dan, Gheorghe, Liliana, Seritean Isac, Petronela Nicoleta, Chetran, Adriana, Leancă, Sabina Andreea, Afrăsânie, Irina, Duca, Ștefania-Teodora, Gorduza, Eusebiu Vlad, Costache, Irina Iuliana, Rezus, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300874/
https://www.ncbi.nlm.nih.gov/pubmed/37374153
http://dx.doi.org/10.3390/life13061371
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author Badescu, Minerva Codruta
Butnariu, Lăcrămioara Ionela
Costache, Alexandru Dan
Gheorghe, Liliana
Seritean Isac, Petronela Nicoleta
Chetran, Adriana
Leancă, Sabina Andreea
Afrăsânie, Irina
Duca, Ștefania-Teodora
Gorduza, Eusebiu Vlad
Costache, Irina Iuliana
Rezus, Ciprian
author_facet Badescu, Minerva Codruta
Butnariu, Lăcrămioara Ionela
Costache, Alexandru Dan
Gheorghe, Liliana
Seritean Isac, Petronela Nicoleta
Chetran, Adriana
Leancă, Sabina Andreea
Afrăsânie, Irina
Duca, Ștefania-Teodora
Gorduza, Eusebiu Vlad
Costache, Irina Iuliana
Rezus, Ciprian
author_sort Badescu, Minerva Codruta
collection PubMed
description Factor V (FV) Leiden and prothrombin G20210A are the most common hereditary thrombophilias. While their role in venous thromboembolism is well known, there are still uncertainties regarding their relationship with arterial thrombotic events, especially coronary ones. Our research, based on an in-depth analysis of the available literature, provides up-to-date information on the relationship between FV Leiden and prothrombin G20210A and acute myocardial infarction. FV Leiden and prothrombin G20210A screening should be implemented only in select cases, such as acute coronary syndrome in young individuals and/or in the absence of traditional cardiovascular risk factors and/or in the absence of significant coronary artery stenosis at angiography. Their identification should be followed by the implementation of optimal control of modifiable traditional cardiovascular risk factors to reduce the risk of recurrent events and genotyping and genetic counseling of all family members of affected cases for proper prophylaxis. An extended dual antiplatelet therapy (DAPT) may be considered, given the lower risk of bleeding under DAPT conferred by FV Leiden.
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spelling pubmed-103008742023-06-29 Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A Badescu, Minerva Codruta Butnariu, Lăcrămioara Ionela Costache, Alexandru Dan Gheorghe, Liliana Seritean Isac, Petronela Nicoleta Chetran, Adriana Leancă, Sabina Andreea Afrăsânie, Irina Duca, Ștefania-Teodora Gorduza, Eusebiu Vlad Costache, Irina Iuliana Rezus, Ciprian Life (Basel) Review Factor V (FV) Leiden and prothrombin G20210A are the most common hereditary thrombophilias. While their role in venous thromboembolism is well known, there are still uncertainties regarding their relationship with arterial thrombotic events, especially coronary ones. Our research, based on an in-depth analysis of the available literature, provides up-to-date information on the relationship between FV Leiden and prothrombin G20210A and acute myocardial infarction. FV Leiden and prothrombin G20210A screening should be implemented only in select cases, such as acute coronary syndrome in young individuals and/or in the absence of traditional cardiovascular risk factors and/or in the absence of significant coronary artery stenosis at angiography. Their identification should be followed by the implementation of optimal control of modifiable traditional cardiovascular risk factors to reduce the risk of recurrent events and genotyping and genetic counseling of all family members of affected cases for proper prophylaxis. An extended dual antiplatelet therapy (DAPT) may be considered, given the lower risk of bleeding under DAPT conferred by FV Leiden. MDPI 2023-06-12 /pmc/articles/PMC10300874/ /pubmed/37374153 http://dx.doi.org/10.3390/life13061371 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Badescu, Minerva Codruta
Butnariu, Lăcrămioara Ionela
Costache, Alexandru Dan
Gheorghe, Liliana
Seritean Isac, Petronela Nicoleta
Chetran, Adriana
Leancă, Sabina Andreea
Afrăsânie, Irina
Duca, Ștefania-Teodora
Gorduza, Eusebiu Vlad
Costache, Irina Iuliana
Rezus, Ciprian
Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
title Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
title_full Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
title_fullStr Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
title_full_unstemmed Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
title_short Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
title_sort acute myocardial infarction in patients with hereditary thrombophilia—a focus on factor v leiden and prothrombin g20210a
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300874/
https://www.ncbi.nlm.nih.gov/pubmed/37374153
http://dx.doi.org/10.3390/life13061371
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