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Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2

Genital herpes is a common sexually transmitted disease mainly caused by herpes simplex virus type 2 (HSV-2), which can increase the risk of HIV transmission and is a major health problem in the world. Thus, it is of great significance to develop new anti-HSV-2 drugs with high efficiency and low tox...

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Autores principales: Yan, Han, Wang, Jie, Yang, Jiayi, Xu, Zhongqiu, Li, Chunxia, Hao, Cui, Wang, Shixin, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300932/
https://www.ncbi.nlm.nih.gov/pubmed/37367689
http://dx.doi.org/10.3390/md21060364
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author Yan, Han
Wang, Jie
Yang, Jiayi
Xu, Zhongqiu
Li, Chunxia
Hao, Cui
Wang, Shixin
Wang, Wei
author_facet Yan, Han
Wang, Jie
Yang, Jiayi
Xu, Zhongqiu
Li, Chunxia
Hao, Cui
Wang, Shixin
Wang, Wei
author_sort Yan, Han
collection PubMed
description Genital herpes is a common sexually transmitted disease mainly caused by herpes simplex virus type 2 (HSV-2), which can increase the risk of HIV transmission and is a major health problem in the world. Thus, it is of great significance to develop new anti-HSV-2 drugs with high efficiency and low toxicity. In this study, the anti-HSV-2 activities of PSSD, a marine sulfated polysaccharide, was deeply explored both in vitro and in vivo. The results showed that PSSD had marked anti-HSV-2 activities in vitro with low cytotoxicity. PSSD can directly interact with virus particles to inhibit the adsorption of virus to the cell surface. PSSD may also interact with virus surface glycoproteins to block virus-induced membrane fusion. Importantly, PSSD can significantly attenuate the symptoms of genital herpes and weight loss in mice after gel smear treatment, as well as reducing the titer of virus shedding in the reproductive tract of mice, superior to the effect of acyclovir. In summary, the marine polysaccharide PSSD possesses anti-HSV-2 effects both in vitro and in vivo, and has potential to be developed into a novel anti-genital herpes agent in the future.
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spelling pubmed-103009322023-06-29 Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2 Yan, Han Wang, Jie Yang, Jiayi Xu, Zhongqiu Li, Chunxia Hao, Cui Wang, Shixin Wang, Wei Mar Drugs Article Genital herpes is a common sexually transmitted disease mainly caused by herpes simplex virus type 2 (HSV-2), which can increase the risk of HIV transmission and is a major health problem in the world. Thus, it is of great significance to develop new anti-HSV-2 drugs with high efficiency and low toxicity. In this study, the anti-HSV-2 activities of PSSD, a marine sulfated polysaccharide, was deeply explored both in vitro and in vivo. The results showed that PSSD had marked anti-HSV-2 activities in vitro with low cytotoxicity. PSSD can directly interact with virus particles to inhibit the adsorption of virus to the cell surface. PSSD may also interact with virus surface glycoproteins to block virus-induced membrane fusion. Importantly, PSSD can significantly attenuate the symptoms of genital herpes and weight loss in mice after gel smear treatment, as well as reducing the titer of virus shedding in the reproductive tract of mice, superior to the effect of acyclovir. In summary, the marine polysaccharide PSSD possesses anti-HSV-2 effects both in vitro and in vivo, and has potential to be developed into a novel anti-genital herpes agent in the future. MDPI 2023-06-18 /pmc/articles/PMC10300932/ /pubmed/37367689 http://dx.doi.org/10.3390/md21060364 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yan, Han
Wang, Jie
Yang, Jiayi
Xu, Zhongqiu
Li, Chunxia
Hao, Cui
Wang, Shixin
Wang, Wei
Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
title Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
title_full Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
title_fullStr Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
title_full_unstemmed Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
title_short Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
title_sort inhibition effects and mechanisms of marine polysaccharide pssd against herpes simplex virus type 2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300932/
https://www.ncbi.nlm.nih.gov/pubmed/37367689
http://dx.doi.org/10.3390/md21060364
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