Cargando…
Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study
Background: Osteoarthritis (OA) is a progressive degenerative disease with an inflammatory background. Chronic myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders characterized by chronic inflammation and a tendency for connective tissue remodeling. Aim: This study aimed to investi...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300951/ https://www.ncbi.nlm.nih.gov/pubmed/37374170 http://dx.doi.org/10.3390/life13061388 |
_version_ | 1785064697457803264 |
---|---|
author | Holik, Hrvoje Krečak, Ivan Lucijanić, Marko Samardžić, Ivan Pilipac, Danijel Vučinić Ljubičić, Ivana Coha, Božena Kitter Pipić, Alma Miškić, Blaženka Zupančić-Šalek, Silva |
author_facet | Holik, Hrvoje Krečak, Ivan Lucijanić, Marko Samardžić, Ivan Pilipac, Danijel Vučinić Ljubičić, Ivana Coha, Božena Kitter Pipić, Alma Miškić, Blaženka Zupančić-Šalek, Silva |
author_sort | Holik, Hrvoje |
collection | PubMed |
description | Background: Osteoarthritis (OA) is a progressive degenerative disease with an inflammatory background. Chronic myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders characterized by chronic inflammation and a tendency for connective tissue remodeling. Aim: This study aimed to investigate the prevalence and associated risk factors of symptomatic OA (sOA) in MPN patients. Patients and methods: A total of 100 consecutive MPN (39 essential-thrombocythemia, 34 polycythemia-vera, 27 myelofibrosis) patients treated in two community hematologic centers were cross-sectionally evaluated. Patients were required to have both symptoms attributable to hip and/or knee OA and radiographic confirmation to be considered as having sOA. Results: The prevalence of hip and/or knee sOA was significantly higher among MPN patients than the previously reported prevalence in the general population of similar age (61% vs. 22%, p < 0.001). Hip sOA was present in 50%, knee sOA in 51% and sOA of both localizations in 41% of patients. A high proportion of MPN patients had radiographic signs of hip OA (94%) and knee OA (98%) in the presence of attributable symptoms. Among the other factors, sOA was univariately associated with the presence of JAK2 mutation, myelofibrosis phenotype, older age, higher body weight, and higher MPN-SAF score (p < 0.050 for all analyses). In the multivariate analysis, older age (odds ratio = 1.19, 95% confidence interval-CI 1.06–1.33) and higher body weight (OR = 1.15, 95% CI 1.06–1.25) were recognized as independent risk factors for sOA. On the other hand, cytoreductive treatment was a protective factor for sOA (OR = 0.07, 95% CI 0.006–0.86). Conclusions: The prevalence of sOA in MPN patients was higher than that in the general population and seems to correlate with older age, increased myeloproliferation and a higher inflammatory state. Whether cytoreductive treatment may postpone OA development in MPN patients warrants additional confirmation. |
format | Online Article Text |
id | pubmed-10300951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103009512023-06-29 Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study Holik, Hrvoje Krečak, Ivan Lucijanić, Marko Samardžić, Ivan Pilipac, Danijel Vučinić Ljubičić, Ivana Coha, Božena Kitter Pipić, Alma Miškić, Blaženka Zupančić-Šalek, Silva Life (Basel) Article Background: Osteoarthritis (OA) is a progressive degenerative disease with an inflammatory background. Chronic myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders characterized by chronic inflammation and a tendency for connective tissue remodeling. Aim: This study aimed to investigate the prevalence and associated risk factors of symptomatic OA (sOA) in MPN patients. Patients and methods: A total of 100 consecutive MPN (39 essential-thrombocythemia, 34 polycythemia-vera, 27 myelofibrosis) patients treated in two community hematologic centers were cross-sectionally evaluated. Patients were required to have both symptoms attributable to hip and/or knee OA and radiographic confirmation to be considered as having sOA. Results: The prevalence of hip and/or knee sOA was significantly higher among MPN patients than the previously reported prevalence in the general population of similar age (61% vs. 22%, p < 0.001). Hip sOA was present in 50%, knee sOA in 51% and sOA of both localizations in 41% of patients. A high proportion of MPN patients had radiographic signs of hip OA (94%) and knee OA (98%) in the presence of attributable symptoms. Among the other factors, sOA was univariately associated with the presence of JAK2 mutation, myelofibrosis phenotype, older age, higher body weight, and higher MPN-SAF score (p < 0.050 for all analyses). In the multivariate analysis, older age (odds ratio = 1.19, 95% confidence interval-CI 1.06–1.33) and higher body weight (OR = 1.15, 95% CI 1.06–1.25) were recognized as independent risk factors for sOA. On the other hand, cytoreductive treatment was a protective factor for sOA (OR = 0.07, 95% CI 0.006–0.86). Conclusions: The prevalence of sOA in MPN patients was higher than that in the general population and seems to correlate with older age, increased myeloproliferation and a higher inflammatory state. Whether cytoreductive treatment may postpone OA development in MPN patients warrants additional confirmation. MDPI 2023-06-14 /pmc/articles/PMC10300951/ /pubmed/37374170 http://dx.doi.org/10.3390/life13061388 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Holik, Hrvoje Krečak, Ivan Lucijanić, Marko Samardžić, Ivan Pilipac, Danijel Vučinić Ljubičić, Ivana Coha, Božena Kitter Pipić, Alma Miškić, Blaženka Zupančić-Šalek, Silva Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study |
title | Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study |
title_full | Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study |
title_fullStr | Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study |
title_full_unstemmed | Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study |
title_short | Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study |
title_sort | hip and knee osteoarthritis in patients with chronic myeloproliferative neoplasms: a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300951/ https://www.ncbi.nlm.nih.gov/pubmed/37374170 http://dx.doi.org/10.3390/life13061388 |
work_keys_str_mv | AT holikhrvoje hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT krecakivan hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT lucijanicmarko hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT samardzicivan hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT pilipacdanijel hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT vucinicljubicicivana hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT cohabozena hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT kitterpipicalma hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT miskicblazenka hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy AT zupancicsaleksilva hipandkneeosteoarthritisinpatientswithchronicmyeloproliferativeneoplasmsacrosssectionalstudy |