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A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface

This article presents a low-cost and flexible software solution for acoustic startle response (ASR) test that can be used with a Spike2-based interface. ASR is a reflexive response to an unexpected, loud acoustic stimulus, and prepulse inhibition (PPI) is a phenomenon in which the startle response i...

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Detalles Bibliográficos
Autores principales: Pelevin, Arseniy, Kurzina, Natalia, Zavialov, Vladislav, Volnova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300963/
https://www.ncbi.nlm.nih.gov/pubmed/37368001
http://dx.doi.org/10.3390/mps6030057
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author Pelevin, Arseniy
Kurzina, Natalia
Zavialov, Vladislav
Volnova, Anna
author_facet Pelevin, Arseniy
Kurzina, Natalia
Zavialov, Vladislav
Volnova, Anna
author_sort Pelevin, Arseniy
collection PubMed
description This article presents a low-cost and flexible software solution for acoustic startle response (ASR) test that can be used with a Spike2-based interface. ASR is a reflexive response to an unexpected, loud acoustic stimulus, and prepulse inhibition (PPI) is a phenomenon in which the startle response is reduced when preceded by a weak prestimulus of the same modality. Measuring PPI is important because changes in PPI have been observed in patients with various psychiatric and neurological disorders. Commercial ASR testing systems are expensive, and their closed source code affects their transparency and result reproducibility. The proposed software is easy to install and use. The Spike2 script is customizable and supports a wide range of PPI protocols. As an example of PPI recording, the article presents data obtained in female rats, both wild-type (WT) and dopamine transporter knockout (DAT-KO), showing the same tendency as the data obtained in males, with ASR on a single pulse higher than ASR on prepulse+pulse, and PPI reduced in DAT-KO rats compared to WT.
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spelling pubmed-103009632023-06-29 A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface Pelevin, Arseniy Kurzina, Natalia Zavialov, Vladislav Volnova, Anna Methods Protoc Article This article presents a low-cost and flexible software solution for acoustic startle response (ASR) test that can be used with a Spike2-based interface. ASR is a reflexive response to an unexpected, loud acoustic stimulus, and prepulse inhibition (PPI) is a phenomenon in which the startle response is reduced when preceded by a weak prestimulus of the same modality. Measuring PPI is important because changes in PPI have been observed in patients with various psychiatric and neurological disorders. Commercial ASR testing systems are expensive, and their closed source code affects their transparency and result reproducibility. The proposed software is easy to install and use. The Spike2 script is customizable and supports a wide range of PPI protocols. As an example of PPI recording, the article presents data obtained in female rats, both wild-type (WT) and dopamine transporter knockout (DAT-KO), showing the same tendency as the data obtained in males, with ASR on a single pulse higher than ASR on prepulse+pulse, and PPI reduced in DAT-KO rats compared to WT. MDPI 2023-06-08 /pmc/articles/PMC10300963/ /pubmed/37368001 http://dx.doi.org/10.3390/mps6030057 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pelevin, Arseniy
Kurzina, Natalia
Zavialov, Vladislav
Volnova, Anna
A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface
title A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface
title_full A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface
title_fullStr A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface
title_full_unstemmed A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface
title_short A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface
title_sort custom solution for acoustic startle response setup with spike2-based data acquisition interface
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300963/
https://www.ncbi.nlm.nih.gov/pubmed/37368001
http://dx.doi.org/10.3390/mps6030057
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