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Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and Valsartan Tablets

Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products markete...

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Detalles Bibliográficos
Autores principales:	Leon, Rosmery Merma, Issa, Michele Georges, Duque, Marcelo Dutra, Daniel, Josiane Souza Pereira, Ferraz, Humberto Gomes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301187/ https://www.ncbi.nlm.nih.gov/pubmed/37376183 http://dx.doi.org/10.3390/pharmaceutics15061735

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