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Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial

Background: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects....

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Autores principales: Flores, Victoria A., Kisiolek, Jacob N., Ramani, Arjun, Townsend, Ryland, Rodriguez, Edwin, Butler, Blake, Stewart, Laura K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301202/
https://www.ncbi.nlm.nih.gov/pubmed/37375567
http://dx.doi.org/10.3390/nu15122664
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author Flores, Victoria A.
Kisiolek, Jacob N.
Ramani, Arjun
Townsend, Ryland
Rodriguez, Edwin
Butler, Blake
Stewart, Laura K.
author_facet Flores, Victoria A.
Kisiolek, Jacob N.
Ramani, Arjun
Townsend, Ryland
Rodriguez, Edwin
Butler, Blake
Stewart, Laura K.
author_sort Flores, Victoria A.
collection PubMed
description Background: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects. Methods: This study aimed to investigate the effects of 8 weeks of CBD on the above-mentioned measures in healthy individuals. Forty-eight participants were randomized into two groups receiving either oral capsules of 50 mg of CBD or a calorie-matched placebo daily. Participants completed pre- and post-intervention assessments, including blood draws, body composition, fitness, physical activity, and self-reported surveys. Results: There were no significant differences between groups regarding body composition, aerobic fitness, muscular strength, physical activity, cognitive health, psychological wellbeing, and resting CRP concentrations. However, the placebo group experienced a decline in mean peak power and relative peak power compared to the CBD group. Conclusions: The results suggest that 8 weeks of CBD supplementation may prevent declines in anaerobic fitness over time. However, long-term CBD supplementation may not be beneficial for altering measures of health-related fitness, mental health, and inflammation in healthy individuals.
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spelling pubmed-103012022023-06-29 Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial Flores, Victoria A. Kisiolek, Jacob N. Ramani, Arjun Townsend, Ryland Rodriguez, Edwin Butler, Blake Stewart, Laura K. Nutrients Article Background: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects. Methods: This study aimed to investigate the effects of 8 weeks of CBD on the above-mentioned measures in healthy individuals. Forty-eight participants were randomized into two groups receiving either oral capsules of 50 mg of CBD or a calorie-matched placebo daily. Participants completed pre- and post-intervention assessments, including blood draws, body composition, fitness, physical activity, and self-reported surveys. Results: There were no significant differences between groups regarding body composition, aerobic fitness, muscular strength, physical activity, cognitive health, psychological wellbeing, and resting CRP concentrations. However, the placebo group experienced a decline in mean peak power and relative peak power compared to the CBD group. Conclusions: The results suggest that 8 weeks of CBD supplementation may prevent declines in anaerobic fitness over time. However, long-term CBD supplementation may not be beneficial for altering measures of health-related fitness, mental health, and inflammation in healthy individuals. MDPI 2023-06-07 /pmc/articles/PMC10301202/ /pubmed/37375567 http://dx.doi.org/10.3390/nu15122664 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Flores, Victoria A.
Kisiolek, Jacob N.
Ramani, Arjun
Townsend, Ryland
Rodriguez, Edwin
Butler, Blake
Stewart, Laura K.
Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
title Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
title_full Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
title_fullStr Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
title_full_unstemmed Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
title_short Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
title_sort effects of oral cannabidiol on health and fitness in healthy adults: an 8-week randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301202/
https://www.ncbi.nlm.nih.gov/pubmed/37375567
http://dx.doi.org/10.3390/nu15122664
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