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Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial
Background: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301202/ https://www.ncbi.nlm.nih.gov/pubmed/37375567 http://dx.doi.org/10.3390/nu15122664 |
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author | Flores, Victoria A. Kisiolek, Jacob N. Ramani, Arjun Townsend, Ryland Rodriguez, Edwin Butler, Blake Stewart, Laura K. |
author_facet | Flores, Victoria A. Kisiolek, Jacob N. Ramani, Arjun Townsend, Ryland Rodriguez, Edwin Butler, Blake Stewart, Laura K. |
author_sort | Flores, Victoria A. |
collection | PubMed |
description | Background: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects. Methods: This study aimed to investigate the effects of 8 weeks of CBD on the above-mentioned measures in healthy individuals. Forty-eight participants were randomized into two groups receiving either oral capsules of 50 mg of CBD or a calorie-matched placebo daily. Participants completed pre- and post-intervention assessments, including blood draws, body composition, fitness, physical activity, and self-reported surveys. Results: There were no significant differences between groups regarding body composition, aerobic fitness, muscular strength, physical activity, cognitive health, psychological wellbeing, and resting CRP concentrations. However, the placebo group experienced a decline in mean peak power and relative peak power compared to the CBD group. Conclusions: The results suggest that 8 weeks of CBD supplementation may prevent declines in anaerobic fitness over time. However, long-term CBD supplementation may not be beneficial for altering measures of health-related fitness, mental health, and inflammation in healthy individuals. |
format | Online Article Text |
id | pubmed-10301202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103012022023-06-29 Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial Flores, Victoria A. Kisiolek, Jacob N. Ramani, Arjun Townsend, Ryland Rodriguez, Edwin Butler, Blake Stewart, Laura K. Nutrients Article Background: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects. Methods: This study aimed to investigate the effects of 8 weeks of CBD on the above-mentioned measures in healthy individuals. Forty-eight participants were randomized into two groups receiving either oral capsules of 50 mg of CBD or a calorie-matched placebo daily. Participants completed pre- and post-intervention assessments, including blood draws, body composition, fitness, physical activity, and self-reported surveys. Results: There were no significant differences between groups regarding body composition, aerobic fitness, muscular strength, physical activity, cognitive health, psychological wellbeing, and resting CRP concentrations. However, the placebo group experienced a decline in mean peak power and relative peak power compared to the CBD group. Conclusions: The results suggest that 8 weeks of CBD supplementation may prevent declines in anaerobic fitness over time. However, long-term CBD supplementation may not be beneficial for altering measures of health-related fitness, mental health, and inflammation in healthy individuals. MDPI 2023-06-07 /pmc/articles/PMC10301202/ /pubmed/37375567 http://dx.doi.org/10.3390/nu15122664 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Flores, Victoria A. Kisiolek, Jacob N. Ramani, Arjun Townsend, Ryland Rodriguez, Edwin Butler, Blake Stewart, Laura K. Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial |
title | Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial |
title_full | Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial |
title_fullStr | Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial |
title_full_unstemmed | Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial |
title_short | Effects of Oral Cannabidiol on Health and Fitness in Healthy Adults: An 8-Week Randomized Trial |
title_sort | effects of oral cannabidiol on health and fitness in healthy adults: an 8-week randomized trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301202/ https://www.ncbi.nlm.nih.gov/pubmed/37375567 http://dx.doi.org/10.3390/nu15122664 |
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