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Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans

Lumpy skin disease virus (LSDV) is a vector-transmitted capripox virus that causes disease in cattle. Stomoxys calcitrans flies are considered to be important vectors as they are able to transmit viruses from cattle with the typical LSDV skin nodules to naive cattle. No conclusive data are, however,...

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Autores principales: Haegeman, Andy, Sohier, Charlotte, Mostin, Laurent, De Leeuw, Ilse, Van Campe, Willem, Philips, Wannes, De Regge, Nick, De Clercq, Kris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301266/
https://www.ncbi.nlm.nih.gov/pubmed/37376585
http://dx.doi.org/10.3390/v15061285
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author Haegeman, Andy
Sohier, Charlotte
Mostin, Laurent
De Leeuw, Ilse
Van Campe, Willem
Philips, Wannes
De Regge, Nick
De Clercq, Kris
author_facet Haegeman, Andy
Sohier, Charlotte
Mostin, Laurent
De Leeuw, Ilse
Van Campe, Willem
Philips, Wannes
De Regge, Nick
De Clercq, Kris
author_sort Haegeman, Andy
collection PubMed
description Lumpy skin disease virus (LSDV) is a vector-transmitted capripox virus that causes disease in cattle. Stomoxys calcitrans flies are considered to be important vectors as they are able to transmit viruses from cattle with the typical LSDV skin nodules to naive cattle. No conclusive data are, however, available concerning the role of subclinically or preclinically infected cattle in virus transmission. Therefore, an in vivo transmission study with 13 donors, experimentally inoculated with LSDV, and 13 naïve acceptor bulls was performed whereby S. calcitrans flies were fed on either subclinical- or preclinical-infected donor animals. Transmission of LSDV from subclinical donors showing proof of productive virus replication but without formation of skin nodules was demonstrated in two out of five acceptor animals, while no transmission was seen from preclinical donors that developed nodules after Stomoxys calcitrans flies had fed. Interestingly, one of the acceptor animals which became infected developed a subclinical form of the disease. Our results show that subclinical animals can contribute to virus transmission. Therefore, stamping out only clinically diseased LSDV-infected cattle could be insufficient to completely halt the spread and control of the disease.
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spelling pubmed-103012662023-06-29 Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans Haegeman, Andy Sohier, Charlotte Mostin, Laurent De Leeuw, Ilse Van Campe, Willem Philips, Wannes De Regge, Nick De Clercq, Kris Viruses Article Lumpy skin disease virus (LSDV) is a vector-transmitted capripox virus that causes disease in cattle. Stomoxys calcitrans flies are considered to be important vectors as they are able to transmit viruses from cattle with the typical LSDV skin nodules to naive cattle. No conclusive data are, however, available concerning the role of subclinically or preclinically infected cattle in virus transmission. Therefore, an in vivo transmission study with 13 donors, experimentally inoculated with LSDV, and 13 naïve acceptor bulls was performed whereby S. calcitrans flies were fed on either subclinical- or preclinical-infected donor animals. Transmission of LSDV from subclinical donors showing proof of productive virus replication but without formation of skin nodules was demonstrated in two out of five acceptor animals, while no transmission was seen from preclinical donors that developed nodules after Stomoxys calcitrans flies had fed. Interestingly, one of the acceptor animals which became infected developed a subclinical form of the disease. Our results show that subclinical animals can contribute to virus transmission. Therefore, stamping out only clinically diseased LSDV-infected cattle could be insufficient to completely halt the spread and control of the disease. MDPI 2023-05-30 /pmc/articles/PMC10301266/ /pubmed/37376585 http://dx.doi.org/10.3390/v15061285 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haegeman, Andy
Sohier, Charlotte
Mostin, Laurent
De Leeuw, Ilse
Van Campe, Willem
Philips, Wannes
De Regge, Nick
De Clercq, Kris
Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans
title Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans
title_full Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans
title_fullStr Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans
title_full_unstemmed Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans
title_short Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans
title_sort evidence of lumpy skin disease virus transmission from subclinically infected cattle by stomoxys calcitrans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301266/
https://www.ncbi.nlm.nih.gov/pubmed/37376585
http://dx.doi.org/10.3390/v15061285
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