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Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?

A previous follow-up of the GINIplus study showed that breastfeeding could protect against early eczema. However, effects diminished in adolescence, possibly indicating a “rebound effect” in breastfed children after initial protection. We evaluated the role of early eczema until three years of age o...

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Autores principales: Libuda, Lars, Filipiak-Pittroff, Birgit, Standl, Marie, Schikowski, Tamara, von Berg, Andrea, Koletzko, Sibylle, Bauer, Carl-Peter, Heinrich, Joachim, Berdel, Dietrich, Gappa, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301269/
https://www.ncbi.nlm.nih.gov/pubmed/37375684
http://dx.doi.org/10.3390/nu15122780
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author Libuda, Lars
Filipiak-Pittroff, Birgit
Standl, Marie
Schikowski, Tamara
von Berg, Andrea
Koletzko, Sibylle
Bauer, Carl-Peter
Heinrich, Joachim
Berdel, Dietrich
Gappa, Monika
author_facet Libuda, Lars
Filipiak-Pittroff, Birgit
Standl, Marie
Schikowski, Tamara
von Berg, Andrea
Koletzko, Sibylle
Bauer, Carl-Peter
Heinrich, Joachim
Berdel, Dietrich
Gappa, Monika
author_sort Libuda, Lars
collection PubMed
description A previous follow-up of the GINIplus study showed that breastfeeding could protect against early eczema. However, effects diminished in adolescence, possibly indicating a “rebound effect” in breastfed children after initial protection. We evaluated the role of early eczema until three years of age on allergies until young adulthood and assessed whether early eczema modifies the association between breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058) were considered. Information on atopic eczema, asthma, and rhinitis was based on reported physician’s diagnoses. Adjusted Odds Ratios (aOR) were modelled by using generalized estimating equations. Early eczema was associated with eczema (aORs = 3.2–14.4), asthma (aORs = 2.2–2.7), and rhinitis (aORs = 1.2–2.7) until young adulthood. For eczema, this association decreased with age (p-for-interaction = 0.002–0.006). Longitudinal models did not show associations between breastfeeding and the respective allergies from 5 to 20 years of age. Moreover, early eczema generally did not modify the association between milk feeding and allergies except for rhinitis in participants without family history of atopy. Early eczema strongly predicts allergies until young adulthood. While preventive effects of full breastfeeding on eczema in infants with family history of atopy does not persist until young adulthood, the hypothesis of a rebound effect after initial protection cannot be confirmed.
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spelling pubmed-103012692023-06-29 Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects? Libuda, Lars Filipiak-Pittroff, Birgit Standl, Marie Schikowski, Tamara von Berg, Andrea Koletzko, Sibylle Bauer, Carl-Peter Heinrich, Joachim Berdel, Dietrich Gappa, Monika Nutrients Article A previous follow-up of the GINIplus study showed that breastfeeding could protect against early eczema. However, effects diminished in adolescence, possibly indicating a “rebound effect” in breastfed children after initial protection. We evaluated the role of early eczema until three years of age on allergies until young adulthood and assessed whether early eczema modifies the association between breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058) were considered. Information on atopic eczema, asthma, and rhinitis was based on reported physician’s diagnoses. Adjusted Odds Ratios (aOR) were modelled by using generalized estimating equations. Early eczema was associated with eczema (aORs = 3.2–14.4), asthma (aORs = 2.2–2.7), and rhinitis (aORs = 1.2–2.7) until young adulthood. For eczema, this association decreased with age (p-for-interaction = 0.002–0.006). Longitudinal models did not show associations between breastfeeding and the respective allergies from 5 to 20 years of age. Moreover, early eczema generally did not modify the association between milk feeding and allergies except for rhinitis in participants without family history of atopy. Early eczema strongly predicts allergies until young adulthood. While preventive effects of full breastfeeding on eczema in infants with family history of atopy does not persist until young adulthood, the hypothesis of a rebound effect after initial protection cannot be confirmed. MDPI 2023-06-16 /pmc/articles/PMC10301269/ /pubmed/37375684 http://dx.doi.org/10.3390/nu15122780 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Libuda, Lars
Filipiak-Pittroff, Birgit
Standl, Marie
Schikowski, Tamara
von Berg, Andrea
Koletzko, Sibylle
Bauer, Carl-Peter
Heinrich, Joachim
Berdel, Dietrich
Gappa, Monika
Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
title Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
title_full Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
title_fullStr Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
title_full_unstemmed Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
title_short Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
title_sort full breastfeeding and allergic diseases—long-term protection or rebound effects?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301269/
https://www.ncbi.nlm.nih.gov/pubmed/37375684
http://dx.doi.org/10.3390/nu15122780
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