Antiplasmodial, Trypanocidal, and Genotoxicity In Vitro Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives

Background: Statins present a plethora of pleiotropic effects including anti-inflammatory and antimicrobial responses. A,α-difluorophenylacetamides, analogs of diclofenac, are potent pre-clinical anti-inflammatory non-steroidal drugs. Molecular hybridization based on the combination of pharmacophori...

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Detalles Bibliográficos
Autores principales: Araujo-Lima, Carlos Fernando, de Cassia Castro Carvalho, Rita, Rosario, Sandra Loureiro, Leite, Debora Inacio, Aguiar, Anna Caroline Campos, de Souza Santos, Lizandra Vitoria, de Araujo, Julianna Siciliano, Salomão, Kelly, Kaiser, Carlos Roland, Krettli, Antoniana Ursine, Bastos, Monica Macedo, Aiub, Claudia Alessandra Fortes, de Nazaré Correia Soeiro, Maria, Boechat, Nubia, Felzenszwalb, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301432/
https://www.ncbi.nlm.nih.gov/pubmed/37375730
http://dx.doi.org/10.3390/ph16060782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301432/
https://www.ncbi.nlm.nih.gov/pubmed/37375730
http://dx.doi.org/10.3390/ph16060782

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